Influence of Square-stepping Exercise on Brain Activation, Cognitive Function and Physical Performance in Frail Elders With MCI
1 other identifier
observational
25
1 country
1
Brief Summary
This study is to elucidate the possible mechanisms of SSE by examining brain activation differences between SSE patterns and usual walking, as well as the relationship between brain activity and SSE performance, between cognitive function and SSE performance, and between physical performance and SSE performance in frail elders with MCI.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Feb 2022
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 5, 2021
CompletedFirst Posted
Study publicly available on registry
December 29, 2021
CompletedStudy Start
First participant enrolled
February 9, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2024
CompletedMay 29, 2025
September 1, 2022
2.1 years
December 5, 2021
May 23, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (9)
Brain activity
The brain activity will be measured under 3 tasks: usual walking, SSE-pattern1 (SSE1), and SSE-pattern 2 (SSE2)
20 minutes
SSE performance
The number of the correct steps that participants complete in 1 min during SSEs will be recorded
15 minutes
Montreal Cognitive Assessment
Global cognitive function
15 minutes
Trail making test
Executive function
5 minutes
Stroop color and word test
Executive function
5 minutes
Digit span test
Executive function
8 minutes
Timed up and go test
Dynamic balance and functional mobility
5 minutes
Berg balance scale
Balance and fall risk
15 minutes
Five times sit to stand test
Lower extremity strength
3 minutes
Study Arms (1)
Older adults with frailty and mild cognitive impairment
Eligibility Criteria
Older adults with frailty and mild cognitive impairment
You may qualify if:
- Age between 65 and 90 years old
- Presence of at least 1 characteristic of the Fried frailty criteria
- Mini-mental state examination score equal to or more than 24
- Montreal Cognitive Assessment score less than 26
- Ability to walk independently for 1 min without assistive devices
You may not qualify if:
- Central nervous system disorders (such as stroke, Parkinson's disease, spinal cord injury)
- Any unstable physical condition, psychiatric disorder, and other neurological disorder or diagnosed with learning disability which may affect participating this study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Yang Ming Chiao Tung University
Taipei, 112, Taiwan
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 5, 2021
First Posted
December 29, 2021
Study Start
February 9, 2022
Primary Completion
February 28, 2024
Study Completion
February 28, 2024
Last Updated
May 29, 2025
Record last verified: 2022-09
Data Sharing
- IPD Sharing
- Will not share