Pancreaticogastrostomy Versus Pancreaticojejunostomy With Dunking Technique After Pancreaticodudenectomy: A Prospective Randomized Comparative Study

NCT05171361 | Unknown

• 1 other identifier: Pancreaticojejunostomy
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

To compare between the outcomes of pancreaticogastrostomy and pancreaticojejunostomy with dunking technique after Pancreaticodudenectomy in the treatment of operable periampullary malignancies.

Conditions

Pancreaticobiliary Cancer

Keywords

pancreaticojejunostomy; pancreaticogastrostomy

Outcome Measures

Primary Outcomes (1)

• Rate of postoperative anastomosis leakage

  Compare between dunking in pancreaticogastrostomy and pancreaticojejunostomy and the rate of postoperative anastomosis leakage

  One month

Study Arms (2)

Pancreaticojejunostomy

With Dunking Technique after Pancreaticodudenectomy

Procedure: Pancreaticogastrostomy versus Pancreaticojejunostomy with Dunking Technique

Pancreaticogastrostomy

With Dunking Technique after Pancreaticodudenectomy

Procedure: Pancreaticogastrostomy versus Pancreaticojejunostomy with Dunking Technique

Interventions

Pancreaticogastrostomy versus Pancreaticojejunostomy with Dunking Technique PROCEDURE

To compare between the outcomes of pancreaticogastrostomy and pancreaticojejunostomy with dunking technique after Pancreaticodudenectomy

Pancreaticogastrostomy; Pancreaticojejunostomy

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All cases of resectable periampullary carcinomas

You may qualify if:

• All cases of resectable periampullary carcinomas (cancer head of pancreas, ampullary carcinoma, distal cholangiocarcinoma and second part of duodenum adenocarcinoma) that are surgically fit according to ASA.

You may not qualify if:

• \. Surgically unfit cases according to ASA 2. Locally advanced irresectable cases
• Abutment or encasement of coeliac trunk
• Encasement of SMA less than 180 degree of its axis
• Encasement of portal/SMV more than 180 degree of its axis or infiltration segment too long more than 2.5 cm that the remaining segment will not coapts after resection.
• \. Metastatic disease

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Cheng Y, Briarava M, Lai M, Wang X, Tu B, Cheng N, Gong J, Yuan Y, Pilati P, Mocellin S. Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction for the prevention of postoperative pancreatic fistula following pancreaticoduodenectomy. Cochrane Database Syst Rev. 2017 Sep 12;9(9):CD012257. doi: 10.1002/14651858.CD012257.pub2.

  PMID: 28898386 BACKGROUND

• Que W, Fang H, Yan B, Li J, Guo W, Zhai W, Zhang S. Pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy: a meta-analysis of randomized controlled trials. Am J Surg. 2015 Jun;209(6):1074-82. doi: 10.1016/j.amjsurg.2014.07.019. Epub 2015 Jan 22.

  PMID: 25743406 BACKGROUND

Central Study Contacts

Sherif Alaa Abdelhafez, Resident

CONTACT

00201004884894; sherifabdelhafez94@gmail.com

Mostafa Mahmoud, Ass. professor

CONTACT

00201118005677; mostafa.sayed@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor

Study Record Dates

• First Submitted: December 10, 2021
• First Posted: December 28, 2021
• Study Start: March 1, 2022
• Primary Completion: March 1, 2023
• Study Completion: April 1, 2023
• Last Updated: December 28, 2021

Record last verified: 2021-12