Efficacy of Providing Eggs as an Early Complementary Food to Promote Child Growth

NCT05168085 | Unknown DMC

• 1 other identifier: Eggcel-growth
• Study Type: interventional
• Target: 655
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the efficacy of providing one chicken egg per day for a period of 6 months, beginning at the age of 6 to \<9 months on the growth, motor development, micronutrient, and morbidity status of infants from a low socioeconomic community in South Africa.

Conditions

Linear Growth

Outcome Measures

Primary Outcomes (1)

• Linear growth by measuring length

  Efficacy of providing one chicken egg per day on linear growth and stunting prevalence compare to a control

  6 months

Secondary Outcomes (3)

• Motor development using Pictorial Gross Motor Milestone Chart

  6 months

• Biomarkers of anaemia, iron, vitamin A and essential fatty acids

  6 months

• Morbidity status

  6 months

Study Arms (2)

Intervention group

EXPERIMENTAL

One chicken egg per day

Dietary Supplement: Eggs

Control group

NO INTERVENTION

True control

Interventions

Eggs DIETARY_SUPPLEMENT

Providing 1 egg per day fo 6 months to infants

Intervention group

Eligibility Criteria

• Age: 6 Months - 9 Months
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Resident in the study municipality; Infants aged 6 to \<9 months

You may not qualify if:

• Severe obvious congenital abnormalities such as cleft lip and spina bifida; Severe anaemia (haemoglobin \<70 g/L); Severe acute malnutrition (weight-for-length z-score \< -3); Plans to move out of the study area in the next nine months; Known allergies/intolerances to eggs; Infants receiving special nutritional supplements as part of feeding programmes; Not been born as a singleton; Mother/legal guardian below 18 years old at the start of the study

Sponsors & Collaborators

• North-West University, South Africa: lead

Study Sites (1)

Jouberton area in the Matlosana sub-district

Klerksdorp, North West, 2574, South Africa

Location

Related Publications (2)

• Nakiranda R, Malan L, Ricci H, Kruger HS, Nienaber A, Visser M, Ricci C, Faber M, Smuts CM. Daily Complementary Feeding With Eggs Improves Fibroblast Growth Factor 21 in Infants. Matern Child Nutr. 2025 Apr;21(2):e13782. doi: 10.1111/mcn.13782. Epub 2024 Dec 9.

  PMID: 39648796 DERIVED

• Ricci H, Faber M, Ricci C, Kruger HS, Malan L, Nakiranda R, Visser M, Smuts CM. Effects of egg as an early complementary food on growth of 6- to 9-month-old infants: a randomised controlled trial. Public Health Nutr. 2023 Nov 29;27(1):e1. doi: 10.1017/S1368980023002604.

  PMID: 38018158 DERIVED

MeSH Terms

Interventions

Eggs

Intervention Hierarchy (Ancestors)

Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Marius Smuts, PhD

  Director

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 13, 2020
• First Posted: December 23, 2021
• Study Start: February 13, 2020
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2023
• Last Updated: August 24, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

ZA (1)