Immune Response to PNEUMOVAX 23 in Healthy Adults Receiving Efgartigimod IV

NCT05163834 | Completed Phase 1

• 2 other identifiers: ARGX-113-21022021-004878-53
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

This is a randomized, open-label, placebo-controlled phase 1 study in healthy adult volunteers to provide information regarding vaccination with a common pneumococcal polysaccharide vaccine while receiving efgartigimod.

Conditions

Healthy Volunteers

Outcome Measures

Primary Outcomes (1)

• Variation in the immune response assessed by comparing pneumococcal capsular polysaccharide (PCP) titers pre- and postadministration of the PNEUMOVAX 23 vaccine between study arms

  throughout the study (up to 12 weeks)

Study Arms (3)

Efgartigimod-1

EXPERIMENTAL

Weekly efgartigimod infusions and the pneumovax 23 vaccine on day 22

Biological: Efgartigimod; Biological: PNEUMOVAX 23

Efgartigimod-2

EXPERIMENTAL

Weekly efgartigimod infusions and the pneumovax 23 vaccine on day 36

Biological: Efgartigimod; Biological: PNEUMOVAX 23

Placebo

PLACEBO COMPARATOR

Weekly placebo infusions and the pneumovax 23 vaccine on day 22

Other: Placebo; Biological: PNEUMOVAX 23

Interventions

Efgartigimod BIOLOGICAL

intravenous infusion of efgartigimod

Efgartigimod-1; Efgartigimod-2

Placebo OTHER

intravenous infusion of placebo

Placebo

PNEUMOVAX 23 BIOLOGICAL

PNEUMOVAX 23 vaccine

Efgartigimod-1; Efgartigimod-2; Placebo

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• At least 18 years of age at the time of signing the informed consent form (ICF)
• Healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring
• Body mass index (BMI) between 18 kg/m2 to 30 kg/m2 (inclusive)
• Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
• Male participants must agree not to donate sperm from the time the ICF was signed until the end of the study
• Women of childbearing potential must have a negative serum pregnancy test at screening and a negative urine pregnancy test at baseline before study intervention can be administered.
• Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the ICF and in this protocol
• Abstains from smoking for at least 3 months prior to screening
• Negative urine drug screen and negative alcohol urine test
• Agrees to restrict excessive strenuous physical activities 96 hours prior to screening, 96 hours prior to the visits in the treatment period, and 96 hours prior to the visits in follow-up period.

You may not qualify if:

• Clinically significant active or chronic bacterial, viral, including or fungal infection at day -1
• History of malignancy unless deemed cured by adequate treatment with no evidence of recurrence for ≥3 years before the first administration of study intervention. Participants with the following cancers can be included at any time: Adequately treated basal cell or squamous cell skin cancer ; Carcinoma in situ of the cervix and Carcinoma in situ of the breast; Incidental histological finding of prostate cancer (TNM stage T1a or T1b).
• Clinical evidence of other significant serious diseases, a recent major surgery, or any other condition that, in the opinion of the investigator, could confound the results of the study or put the participant at undue risk
• Use of an investigational product within 2 months or 5 half-lives (whichever is longer) before the first dose of study intervention; Use of any monoclonal antibody within 3 months prior to the initial study intervention administration; Use of any systemic immunosuppressant agent within 6 months prior to the initial study intervention administration; Use of any systemic steroid within 3 months prior to the initial study intervention administration; Use of B-cell depleting agents in the year before the initial screening visit
• Previously participated in a clinical study with efgartigimod and received at least 1 dose of efgartigimod
• Positive serum test screening for an active viral infection with any of the following conditions: Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human immunodeficiency virus (HIV) based on test results that are associated with an acquired immunodeficiency syndrome (AIDS)-defining condition, or a CD4 count ≤200 cells/mm3.
• Positive nasopharyngeal swab antigen test for SARS-CoV-2 on day -1. Any contact with SARS-CoV-2 positive or COVID-19 patients within the last 2 weeks prior to admission.
• Total IgG ≤6 g/L at screening
• Current or history of (ie, within 12 months of screening) alcohol, drug, or medication abuse
• Known hypersensitivity reaction to any of the excipients of study intervention, the PNEUMOVAX 23 vaccine, or any of its excipients
• Pregnant or lactating females and those who intend to become pregnant during the study or within 90 days after the last dose of study intervention
• Received a pneumococcal vaccine within the past 10 years
• Documented pneumococcal infection within the past 5 years prior to first administration of the study intervention
• Has a clinically relevant abnormality detected on ECG recording regarding either rhythm or conduction. A first-degree heart block or sinus arrhythmia will not be considered a significant abnormality.
• Had significant blood loss (including blood donation ≥500 mL) within 12 weeks prior to the (first) study intervention administration

Sponsors & Collaborators

• argenx: lead

Study Sites (1)

Investigator site 1

Groningen, 9728 NZ, Netherlands

Location

MeSH Terms

Interventions

efgartigimod alfa; 23-valent pneumococcal capsular polysaccharide vaccine

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 23, 2021
• First Posted: December 20, 2021
• Study Start: November 17, 2021
• Primary Completion: March 8, 2022
• Study Completion: March 8, 2022
• Last Updated: March 17, 2022

Record last verified: 2022-03

Locations

NL (1)