The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR)

NCT05163600 | Recruiting

• 1 other identifier: 2021-02038
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens. Furthermore, the investigators hypothesize that these patterns differ between healthy participants and participants with COPD. Regarding secondary objective, the investigators hypothesize that BFR results in lower blood pressure responses compared to traditional exercise training in both healthy and COPD participants.

Conditions

COPD

Outcome Measures

Primary Outcomes (1)

• Within-subject difference in maximal minute ventilation (VE) between BFR and traditional exercise regimens

  investigators will examine VE during strength training and endurance training with and without BFR. Each training sessions will last approximately 20 minutes including baseline CPET. There will be no measurements between the trainings. There will be a minimum wait of 48 hours (wash out timne) until training 2 is performed.

  basline (CPET) 20 min, V1 Training (endurance or strengthwith) with or without BFR 20 min; V2 Training (endurance or strengthwith) with or without BFR 20 min

Study Arms (2)

COPD

EXPERIMENTAL

Diagnosed COPD according to GOLD-guidelines

Other: Blod flow restriction training

Healthy

EXPERIMENTAL

Age ≥ 18 years Clinically healthy

Other: Blod flow restriction training

Interventions

Blod flow restriction training OTHER

includes one strength and one endurance training

COPD; Healthy

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 years
• Clinically healthy

You may not qualify if:

• Physical or intellectual impairment precluding informed consent or protocol adherence
• Non-German speaking (precluding informed consent)
• Pain during exercise of any origin
• Pregnancy
• History of thromboembolic event in the lower extremity
• Resting systolic blood pressure \<100 mmHg
• Age ≥ 18 years
• Diagnosed COPD according to GOLD-guidelines12
• Physical or intellectual impairment precluding informed consent or protocol adherence
• Non-German speaking (precluding informed consent)
• Acute or recent (within the last 6 weeks) exacerbation of COPD
• Pain during exercise of any origin
• Pregnancy
• History of thromboembolic event in the lower extremity
• Resting systolic blood pressure \<100 mmHg

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

University Hospital Zürich

Zurich, 8091, Switzerland

RECRUITING

Related Publications (1)

• Kuhn M, Clarenbach CF, Klay A, Kohler M, Mayer LC, Luchinger M, Andrist B, Radtke T, Haile SR, Sievi NA, Kohlbrenner D. Exploring immediate cardiorespiratory responses: low-intensity blood flow restricted cycling vs. moderate-intensity traditional exercise in a randomized crossover trial. BMC Sports Sci Med Rehabil. 2024 Aug 15;16(1):172. doi: 10.1186/s13102-024-00951-0.

  PMID: 39148127 DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Christian Clarenbach, Dr. med

  University of Zurich

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christan Clarenbach, Dr. med

CONTACT

044 255 22 21; Christian.clarenbach@usz.ch

Manuel Kuhn, PhD Student

CONTACT

0798526722; manuel.kuhn@usz.ch

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PD Dr. med Head of Pneumology

Model Details: monocenter

Study Record Dates

• First Submitted: December 3, 2021
• First Posted: December 20, 2021
• Study Start: May 20, 2022
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: May 29, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)