Transcranial Alternating Current Stimulation (tACS) for Auditory Hallucinations
Intervention Treatment of Auditory Hallucination by Transcranial Alternating Current Stimulation
1 other identifier
interventional
30
1 country
1
Brief Summary
Transcranial alternating current stimulation (tACS) can modulate and restore neural oscillations that are reduced in patients with psychiatric illnesses such as schizophrenia. Here, we performed a open-lable study of clinical trial in 30 schizophrenia patients with auditory hallucinations to show that tACS is effective for auditory hallucinations.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable schizophrenia
Started Nov 2021
Shorter than P25 for not_applicable schizophrenia
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 10, 2021
CompletedStudy Start
First participant enrolled
November 16, 2021
CompletedFirst Posted
Study publicly available on registry
December 16, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 30, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
May 28, 2023
CompletedDecember 16, 2021
November 1, 2021
1.4 years
November 10, 2021
December 2, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
Evaluation of Auditory Hallucination Scale(the minimum is 0, maximum value is 47, and higher scores mean a worse outcome)
Reduction rate of AHRS scale
One month
Study Arms (1)
schizophrenia patients with auditory hallucinations
EXPERIMENTALFor schizophrenia patients with auditory hallucinations, tACS for implementation intervention
Interventions
a 20 weeks, weekly 40 minutes, 1mA, 10Hz-tACS protocol
Eligibility Criteria
You may qualify if:
- Schizophrenia with auditory hallucinations was diagnosed by DSM-IV, AHRS \>12, Take sufficient antipsychotics for at least 1 month.
You may not qualify if:
- current pregnancy, major medical illness affecting the central nervous system, significant neurologic disorders, intake of drugs including supplements like essential fatty acids that influence prostaglandins or niacin skin flush flash pathway metabolism, a history of suicide risk, or alcohol or drug abuse.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Shanghai Mental Health Center
Shanghai, 021, China
Related Publications (2)
Force RB, Riddle J, Jarskog LF, Frohlich F. A case study of the feasibility of weekly tACS for the treatment of auditory hallucinations in schizophrenia. Brain Stimul. 2021 Mar-Apr;14(2):361-363. doi: 10.1016/j.brs.2021.01.014. Epub 2021 Jan 27. No abstract available.
PMID: 33515747RESULTAhn S, Mellin JM, Alagapan S, Alexander ML, Gilmore JH, Jarskog LF, Frohlich F. Targeting reduced neural oscillations in patients with schizophrenia by transcranial alternating current stimulation. Neuroimage. 2019 Feb 1;186:126-136. doi: 10.1016/j.neuroimage.2018.10.056. Epub 2018 Oct 24.
PMID: 30367952RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yegang Hu, Doctor
Shanghai Mental Health Center
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 10, 2021
First Posted
December 16, 2021
Study Start
November 16, 2021
Primary Completion
March 30, 2023
Study Completion
May 28, 2023
Last Updated
December 16, 2021
Record last verified: 2021-11
Data Sharing
- IPD Sharing
- Will not share