Association Between Renal Reserve Function and Progression of Renal Function to Predict CKD Risk in Thai Elderly

NCT05158959 | Unknown

• 1 other identifier: IRB NO.527/62
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates renal functional reserve in elderly.

Conditions

Elder; Renal Function Abnormal

Keywords

Renal functional reserve, CKD progression, Elderly

Outcome Measures

Primary Outcomes (1)

• Change of renal functional reserve per 12 months (mL/min)

  Renal functional reserve defined as the difference between baseline creatinine clearance and creatinine clearance achieved under stimulation with amino acid infusion.

  12 months

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Elders age more than 60 years who are non-frail and has no limited life expectancy

You may qualify if:

• Patient age \> 60 years at screening
• Patient willing to participate in the study and can provide inform consent
• Patient have residual kidney function ≤ 90 ml/min/1.73m2 by CKD-EPI equation

You may not qualify if:

• Patient active smoking
• Patient have Charlson comorbidity index \> .....
• Patient active cancer
• Patient contraindications for blood collection
• Patients with a history of hypersensitivity to cimetidine or amino acid IV solution

Sponsors & Collaborators

• Chulalongkorn University: lead

Study Sites (1)

Kearkiat Praditpornsilpa

Bangkok, 10330, Thailand

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 12 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine

Study Record Dates

• First Submitted: December 2, 2021
• First Posted: December 15, 2021
• Study Start: October 24, 2019
• Primary Completion: June 30, 2022
• Study Completion: December 30, 2022
• Last Updated: December 15, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)