Efficacy of Pericapsular Nerve Group Block

NCT05154318 | Unknown

• 1 other identifier: UW21-382
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Hip fracture is a common orthpaedic problem especially in elderly population. Fascia iliaca compartment block (FICB) and femoral nerve block are well-established technique as part of peri-operative multimodal analgesia for hip fractures. Reviews have shown peripheral nerve blocks including FICB, femoral nerve block and 3-in-1 block could reduce both pain and opioid consumption compared with systematic analgesia. However, there are also literature suggesting that some nerves that account for the major hip joint sensory innervation are not consistently covered. As a result, a new ultrasound guided regional technique, Pericapsular Nerve Group Block (PENG) was introduced in 2018. The primary aim of this study is to compare the analgesic effect of PENG block and FICB in terms of pain score during post-operative period. It also compares the range of movement, quadriceps power and other parameters related to physical functions of the operated hip as secondary outcomes.

Conditions

Acute Pain

Outcome Measures

Primary Outcomes (1)

• Pain score at rest on postoperative day 1

  Measure pain score at rest using numerical rating scale from 0 to 10, where 0 is no pain and 10 is the worst pain

  on postoperative day 1

Study Arms (2)

Pericapsular Nerve Group Block

EXPERIMENTAL

30ml 0.3% Ropivacaine will be injected between psoas muscle and iliopubic eminence.

Procedure: Pericapsular Nerve Group Block

Fascia iliaca compartment block

ACTIVE COMPARATOR

30ml 0.3% Ropivacaine will be injected into fascia iliaca compartment.

Procedure: Fascia iliaca compartment block

Interventions

Pericapsular Nerve Group Block PROCEDURE

Nerve block targeting major hip joint sensory nerves.

Pericapsular Nerve Group Block

Fascia iliaca compartment block PROCEDURE

Routine nerve block for hip fracture surgery.

Fascia iliaca compartment block

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ASA I-II
• Age 18 or above
• Scheduled for hip fracture corrective surgery in Queen Mary Hospital
• Chinese patients
• Able to provide informed oral and written consent
• Abbreviated Mental Test (AMT) 7 or above

You may not qualify if:

• Patient refusal
• ASA III or above
• Allergy to local anaesthetics, opioids, paracetamol, NSAID including COX-2 inhibitors
• Operation delayed for more than 2 days on admission
• Pre-existing peripheral neuropathy or history of stroke
• Preoperative non-walker
• Pre-existing osteoarthritis of knee (KL grade 4)
• Multiple fractures (additional to hip fracture)
• Sepsis
• Impaired renal function (Defined as preoperative creatinine level \>120 μmol or eGFR \<50% of normal reference for their age group
• Patient with coagulopathy (Platelet \< 100 or INR \>1.5)
• Prior surgery at the inguinal or supra-inguinal area

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (1)

Timmy Chan

Hong Kong, Hong Kong

RECRUITING

MeSH Terms

Conditions

Acute Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Timmy CW Chan, MBBS

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Timmy CW Chan, MBBS

CONTACT

22555679; timmychancw@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: November 29, 2021
• First Posted: December 13, 2021
• Study Start: November 15, 2021
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2024
• Last Updated: December 1, 2023

Record last verified: 2023-11

Locations

HK (1)