The Relationship Between Hormone Sensitivity and Imaging of Idiopathic Interstitial Pneumonia by Artificial Intelligence

NCT05146934 | Completed DMC

• 1 other identifier: LM2019173
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Application of artificial intelligence deep learning algorithm to analyze the relationship between hormone sensitivity of idiopathic interstitial pneumonia and imaging features of high resolution CT.

Conditions

Idiopathic Interstitial Pneumonia

Keywords

Hormone sensitivity; imaging features; artificial intelligence

Outcome Measures

Primary Outcomes (1)

• clinical data and imaging feature ratios in both groups

  clinical data including ages，gender，symptoms,signs,smoking history,complications,laboratory examination，lung function. Imaging feature including ground-glass opacity, reticulation, honeycomb and consolidation.

  3-6 months after medication

Secondary Outcomes (1)

• the relationship between imaging feature ratios and hormone sensibility

  3-6 months after medication

Other Outcomes (1)

• development of artificial intelligence algorithm model

  3-6 months after medication

Study Arms (2)

Hormone sensitive group

Prednisone, 0.5mg/kgqd, 3-6months

Radiation: high resolution CT

Hormone insensitivity group

Prednisone, 0.5mg/kgqd, 3-6months

Radiation: high resolution CT

Interventions

high resolution CT RADIATION

Ground glass，honeycomb，reticulation, consolidation

Hormone insensitivity group; Hormone sensitive group

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

From June 1, 2012 to December 31, 2020, all inpatients with IIP were admitted to the respiratory and critical care department of the Third Hospital of Peking University. Total patients are 150, 45 patients using hormone, average age 62 years old, 21 male.

You may qualify if:

• Clinical-pathological-radiology diagnosis of idiopathic interstitial pneumonia Hormone therapy was used; The follow-up data were complete, and the effect of hormone use could be judged.

You may not qualify if:

• Lung infection disease; Heart failure; Connective tissue disease; IIP Without hormone therapy ; IIP but the follow-up data were incomplete, and the effect of hormone use could not be judged.

Sponsors & Collaborators

• Peking University Third Hospital: lead

Study Sites (1)

Peking University Third Hospital

Beijing, Beijing Municipality, 100191, China

Location

MeSH Terms

Conditions

Idiopathic Interstitial Pneumonias

Condition Hierarchy (Ancestors)

Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis; Lung Diseases, Interstitial; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Bei He

  Peking University Third Hospital Respiratory and critical care department

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 30, 2021
• First Posted: December 7, 2021
• Study Start: December 30, 2019
• Primary Completion: June 1, 2021
• Study Completion: June 30, 2021
• Last Updated: December 7, 2021

Record last verified: 2021-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)