Japanese Idiopathic Interstitial Pneumonias Registry

NCT03041623 | Active Not Recruiting

• 1 other identifier: NEJ030
• Study Type: observational
• Target: 867
• Locations: 1 country
• Sites: 86

Brief Summary

An objective of JIPS Registry is to examine disease behavior of idiopathic interstitial pneumonias (IIPs), considering classification, background, and diagnostic methods based on American Thoracic Society (ATS)/ European Respiratory Society(ERS) /Japanese Respiratory Society (JRS)/ Latin American Thoracic Association (ALAT) guidelines for diagnosis and the ATS/ERS classification of 2002 and 2013.

Conditions

Idiopathic Interstitial Pneumonia

Keywords

IIPs

Outcome Measures

Primary Outcomes (3)

• Data on current practice patterns for diagnosis of IIPs

  Describe the frequency of surgical lung biopsy, bronchoalveolar lavage.

  3-4 years

• Prevalence of each categorized IIPs

  Investigate the prevalence of each categorized IIPs by using a recent guideline

  3-4 years

• Natural history of each categorized IIPs

  Describe the natural history of each categorized IIPs, focusing on CT findings, FVC changes, medications, and causes of death.

  3-4 years

Secondary Outcomes (7)

• Progression-free survival by category of IIPs

  3-6 years

• Hospital admission for acute exacerbations of IIPs

  3-6 years

• Mean change of patient-reported outcome (Saint George Respiratory Questionnaire, COPD assessment test, and Dyspnoea-12) every12 months from baseline

  3-4 years

• Quantitative evaluation of CT findings

  3-6 years

• Validation of second multidisciplinary discussion

  3-4 years

Eligibility Criteria

• Age: 20 Years - 84 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Newly diagnosed IIPs within 6 months before registration

You may qualify if:

• Patients aged between 20 and 84 years
• Patients with idiopathic pulmonary fibrosis (IPF) and other IIPs diagnosis within 6 months before registration at each facility
• Patients from whom written informed consent has been obtained regarding participation in this study and follow-up observation

You may not qualify if:

• Patients for whom the tests (such as the lung function test) conducted in this study could not be performed
• Patients who underwent pulmonary resection
• Patients undergoing dialysis
• Patients with cancer treated at the time of registration or those planning to receive treatment in the future

Sponsors & Collaborators

• North East Japan Study Group: lead
• Boehringer Ingelheim: collaborator

Study Sites (86)

Haruhi Respiratory Medical Hospital

Kiyosu, Aichi-ken, 452-0962, Japan

Location

Nagoya University Hospital

Nagoya, Aichi-ken, 466-8560, Japan

Location

Nagoya City University Hospital

Nagoya, Aichi-ken, 467-8601, Japan

Location

Tosei General Hospital

Seto, Aichi-ken, 489-8642, Japan

Location

Fujita Health University Hospital

Toyoake, Aichi-ken, 470-1192, Japan

Location

Hirosaki University Hospital

Hirosaki, Aomori, 036-8562, Japan

Location

Chiba University Hospital

Chiba, Chiba, 260-8677, Japan

Location

National Hospital Organization Chiba-East-Hospital

Chiba, Chiba, 260-8712, Japan

Location

Kameda Medical Center

Kamogawa, Chiba, 296-8602, Japan

Location

Ehime Prefectural Central Hospital

Matsuyama, Ehime, 790-0024, Japan

Location

University of Fukui Hospital

Yoshida, Fukui, 910-1193, Japan

Location

Fukuoka University Chikushi Hospital

Chikushino-shi, Fukuoka, 818-8502, Japan

Location

Kyushu University Hospital.

Fukuoka, Fukuoka, 812-8582, Japan

Location

Fukuoka University Hospital

Fukuoka, Fukuoka, 814-0180, Japan

Location

Aso Iizuka Hospital

Iizuka, Fukuoka, 820-8505, Japan

Location

Kurume University Hospital

Kurume, Fukuoka, 830-0011, Japan

Location

Fukushima Medical University Hospital

Fukushima, Fukushima, 960-1295, Japan

Location

Ogaki Municipal Hospital

Ōgaki, Gifu, 503-8502, Japan

Location

Gunma University Hospital

Maebashi, Gunma, 371-8511, Japan

Location

Hiroshima Prefectural Hospital

Hiroshima, Hiroshima, 734-8530, Japan

Location

Hiroshima University Hospital

Hiroshima, Hiroshima, 734-8551, Japan

Location

Asahikawa Medical University Hospital

Asahikawa, Hokkaido, 078-8510, Japan

Location

Sapporo Medical University Hospital

Sapporo, Hokkaido, 060-8543, Japan

Location

University of Occupational and Environmental Health Japan

Kitakyushu, Hukuoka, 807-8555, Japan

Location

National Hospital Organization Himeji Medical Center

Himeji, Hyōgo, 670-8520, Japan

Location

Kobe City Medical Center General Hospital

Kobe, Hyōgo, 650-0047, Japan

Location

Kobe City Medical Center West Hospital

Kobe, Hyōgo, 653-0013, Japan

Location

Ibarakihigashi National Hospital

Naka, Ibaraki, 319-1113, Japan

Location

Kanazawa University Hospital

Kanazawa, Ishikawa-ken, 920-8641, Japan

Location

Iwate Prefectural Central Hospital

Morioka, Iwate, 020-0066, Japan

Location

Kagoshima University Hospital

Kagoshima, Kagoshima-ken, 890-8520, Japan

Location

Tokai University Hospital

Isehara, Kanagawa, 259-1193, Japan

Location

St. Marianna University School of Medicine Hospital

Kawasaki, Kanagawa, 216-8511, Japan

Location

Showa University Fujigaoka Hospital

Yokohama, Kanagawa, 227-8501, Japan

Location

Kanagawa Cardiovascular and Respiratory Center

Yokohama, Kanagawa, 236-0051, Japan

Location

Kochi medical School Hospital

Nankoku, Kochi, 783-8505, Japan

Location

Kumamoto University Hospital

Kumamoto, Kumamoto, 860-8556, Japan

Location

Saiseikai Kumamoto Hospital

Kumamoto, Kumamoto, 861-4193, Japan

Location

Kyoto University Hospital

Kyoto, Kyoto, 606-8507, Japan

Location

Japanese Red Cross Ise Hospital

Ise, Mie-ken, 516-8512, Japan

Location

Matsuzaka City Hospital

Matsuzaka, Mie-ken, 515-8544, Japan

Location

Sendai Kousei Hospital

Sendai, Miyagi, 980-0873, Japan

Location

Tohoku Medical and Pharmaceutical University Hospital

Sendai, Miyagi, 983-8512, Japan

Location

Suwa Central Hospital

Chino, Nagano, 391-8503, Japan

Location

Shinshu University Hospital

Matsumoto, Nagano, 390-8621, Japan

Location

Saku Central Hospital Advanced Care Center

Saku, Nagano, 385-0051, Japan

Location

Nagasaki University Hospital

Nagasaki, Nagasaki, 852-8510, Japan

Location

Tenri Hospital

Tenri, Nara, 632-8552, Japan

Location

Niigata University Medical and Dental Hospital

Niigata, Niigata, 951-8510, Japan

Location

Kurashiki Central Hospital

Kurashiki, Okayama-ken, 710-8602, Japan

Location

National Hospital Organization Minami-Okayama Medical Center

Okayama, Okayama-ken, 701-0304, Japan

Location

Okinawa Chubu Hospital

Uruma, Okinawa, 904-2293, Japan

Location

National Hospital Organization Kinki-chuo Chest Medical Center

Sakai, Osaka, 591-8555, Japan

Location

Kinki University Hospital

Sayama, Osaka, 589-8511, Japan

Location

Dokkyo Medical University Koshigaya Hospital

Koshigaya, Saitama, 343-8555, Japan

Location

Japanese Red Cross Saitama Hospital

Saitama, Saitama, 330-8553, Japan

Location

Shiga University of Medical Science Hospital

Ōtsu, Shiga, 520-2192, Japan

Location

Shimane University Hospital

Izumo, Shimane, 693-8501, Japan

Location

National Hospital Organization Matsue Medical Center

Matsue, Shimane, 690-8556, Japan

Location

Hamamatsu Rosai Hospital

Hamamatsu, Shizuoka, 430-8525, Japan

Location

Seirei Hamamatsu General Hospital

Hamamatsu, Shizuoka, 430-8558, Japan

Location

Hamamatsu University Hospital

Hamamatsu, Shizuoka, 431-3126, Japan

Location

Seirei Mikatahara General Hospital

Hamamatsu, Shizuoka, 433-8558, Japan

Location

Jichi Medical University

Shimotsuke, Tochigi, 329-0498, Japan

Location

Dokkyo Medical University Hospital

Tochigi, Tochigi, 321-0293, Japan

Location

Tokushima University Hospital

Tokushima, Tokushima, 770-8053, Japan

Location

National Hospital Organization Tokyo National Hospital

Kiyose, Tokyo, 204-8585, Japan

Location

Kyorin University Hospital

Mitaka, Tokyo, 181-8611, Japan

Location

Toranomon Hospital

Tokyo, Tokyo, 105-8470, Japan

Location

The Jikei University Hospital

Tokyo, Tokyo, 105-8471, Japan

Location

Juntendo University Hospital

Tokyo, Tokyo, 113-8431, Japan

Location

Tokyo Medical and Dental University

Tokyo, Tokyo, 113-8519, Japan

Location

Nippon Medical School Hospital

Tokyo, Tokyo, 113-8603, Japan

Location

Tokyo University Hospital

Tokyo, Tokyo, 113-8655, Japan

Location

NTT Medical Center Tokyo

Tokyo, Tokyo, 141-8625, Japan

Location

Toho University Omori Medical Center

Tokyo, Tokyo, 143-8541, Japan

Location

Japanese Red Cross Medical Center

Tokyo, Tokyo, 150-8935, Japan

Location

JR Tokyo General Hospital

Tokyo, Tokyo, 151-8528, Japan

Location

National Hospital Organization Tokyo Medical Center

Tokyo, Tokyo, 152-8902, Japan

Location

National Center for Global Health and Medicine

Tokyo, Tokyo, 162-8655, Japan

Location

Teikyo University Hospital

Tokyo, Tokyo, 173-8605, Japan

Location

Nihon University Itabashi Hospital

Tokyo, Tokyo, 173-8610, Japan

Location

Tottori University Hospital

Yonago, Tottori, 683-0853, Japan

Location

Toyama University Hospital

Toyama, Toyama, 930-0194, Japan

Location

Yamagata City Hospital Saiseikan

Yamagata, Yamagata, 990-8533, Japan

Location

National Hospital Organization Yamaguchi-Ube Medical Center

Ube, Yamaguchi, 755-0241, Japan

Location

Related Publications (2)

• Okuda R, Ogura T, Hisata S, Baba T, Kondoh Y, Suda T, Johkoh T, Iwasawa T, Tomioka H, Bando M, Azuma A, Inoue Y, Ishikawa N, Arai N, Takihara T, Hamaguchi M, Arai T, Nakamura Y, Miyamoto A, Tomii K, Miyazaki Y, Chiba H, Ishii H, Hamada N, Terasaki Y, Fukuoka J, Sakai F, Egashira R, Fujimoto K, Sumikawa H, Suzuki T, Sakamoto S, Nishioka Y, Hattori N, Hashimoto N, Morita S, Ichihara N, Miyata H, Hagiwara K, Kobayashi K, Nukiwa T; JIPS registry collaborators. Prognostic prediction for newly diagnosed patients with idiopathic interstitial pneumonia: JIPS Registry (NEJ030). Respir Investig. 2025 May;63(3):365-372. doi: 10.1016/j.resinv.2025.02.009. Epub 2025 Mar 17.

  PMID: 40101437 DERIVED

• Okuda R, Ogura T, Hisata S, Baba T, Kondoh Y, Suda T, Johkoh T, Iwasawa T, Tomioka H, Bando M, Azuma A, Inoue Y, Arai T, Nakamura Y, Miyamoto A, Miyazaki Y, Chiba H, Ishii H, Hamada N, Terasaki Y, Kuwahira I, Sato S, Kato S, Suzuki T, Sakamoto S, Nishioka Y, Hattori N, Hashimoto N, Morita S, Ichihara N, Miyata H, Hagiwara K, Nukiwa T, Kobayashi K. Design and rationale of the Japanese Idiopathic Interstitial Pneumonias (JIPS) Registry. Respir Investig. 2023 Jan;61(1):95-102. doi: 10.1016/j.resinv.2022.08.009. Epub 2022 Nov 15.

  PMID: 36580379 DERIVED

MeSH Terms

Conditions

Idiopathic Interstitial Pneumonias

Condition Hierarchy (Ancestors)

Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis; Lung Diseases, Interstitial; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Takashi Ogura, MD

  Kanagawa Cardiovascular and Respiratory Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 18, 2016
• First Posted: February 3, 2017
• Study Start: December 1, 2016
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): March 1, 2027
• Last Updated: February 5, 2026

Record last verified: 2026-02

Locations

JP (86)