The Effect of Tai Chi Exercise Among Elders With Sarcopenia

NCT05145036 | Completed

• 1 other identifier: CMUH110-REC2-107
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Sarcopenia has been defined as a disease which presented as low muscles strength, low muscle quantity or quality and low physical activity. The prevalence of sarcopenia is increasing with the age and it is also included in one of geriatric syndromes. Several criteria have been mentioned for diagnosis of sarcopenia, such as European Working Group on Sarcopenia in Older People (EWGSOP)、Foundation for the National Institutes of Health Biomarkers Consortium Sarcopenia Project (FNIH) and Asian Working Group for Sarcopenia (AWGS). In European, the prevalence rate of sarcopenia is 9.25-18%; 5-7% Canadian and 14.4% Taiwanese elders have been diagnosed as sarcopenia, respectively. The sarcopenia has been found its relationship with adverse outcomes of fall down, fracture, disability, and death. The cytokines and decline in anabolic hormones play a role in the pathogenesis of sarcopenia. Tai Chi exercise is one of Qigong and well-popular in Chinese population, and is helpful to integration of body movements. Tai Chi exercise is less complicated and emphasized people's awareness of self-care which presented the relationship between human and nature. Tai Chi exercise could improve muscle performance, balance and have the benefit for fall down prevention in the elders and patients with frailty. Furthermore, Tai Chi has been found that it also could improve the muscle power and power strength in sarcopenic elders by team training. Furthermore, immune makers of inflammation process have been noted their diminishments by Qigong intervention. The aim of this study is to investigate the effect of Tai Chi exercise in sarcopenic elders through practicing at home. The differences of muscles strength, muscle quantity or quality and physical activity after interventions would be recorded and analyzed. The cytokines related to the sarcopenia process would also be sampled.

Conditions

Sarcopenia in Elderly; Tai Chi

Outcome Measures

Primary Outcomes (6)

• Appendicular skeletal muscle mass in kilograms

  The appendicular skeletal muscle mass is evaluated by bioelectrical impedance (BIA) analysis

  baseline

• Change from baseline appendicular skeletal muscle mass at 8 weeks

  The appendicular skeletal muscle mass is evaluated by bioelectrical impedance (BIA) analysis

  8 weeks

• Hand grip in kilograms

  The muscle strength is evaluated with the hand-grip strength (kg) by dynamometer

  baseline

• Hand grip in kilograms

  The muscle strength is evaluated with the hand-grip strength (kg) by dynamometer

  8 weeks

• Times Chair-stand test (5-CST) in minutes

  The 5CST is evaluated by recording the total time that patient repeat 5 times stand and sit motion from chair

  baseline

• Times Chair-stand test (5-CST) in minutes

  The 5CST is evaluated by recording the total time that patient repeat 5 times stand and sit motion from chair

  8 weeks

Study Arms (2)

Tai Chi exercise

ACTIVE COMPARATOR

In addition to standard of care participants will be asked to apply Tai Chi. There are 8 movements. Each session consisted of 10 minutes of warm-up, 40 minutes of Tai Chi, and 10 minutes of cool down. The 8 movements are: Ward-off, Rollback, Push, Press, Grab, Split, Elbow strike, and shoulder strike.

Behavioral: Tai-Chi

Comprehensive training

ACTIVE COMPARATOR

In addition to standard of care participants will be asked to apply Comprehensive training. There are 3 exercises. Each session consisted of 10 minutes of warm-up, 40 minutes of Tai Chi, and 10 minutes of cool down. The 8 movements are: stretch exercise, strengthening exercise, and balance exercise.

Behavioral: Comprehensive training

Interventions

Tai-Chi BEHAVIORAL

Tai Chi exercise could improve muscle performance, balance and have the benefit for fall down prevention in the elders and patients with frailty.

Also known as: Ward-off, Rollback, Push, Press, Grab, Split, Elbow Strike, Shoulder Strike

Tai Chi exercise

Comprehensive training BEHAVIORAL

There are 3 exercises. Each session consisted of 10 minutes of warm-up, 40 minutes of Tai Chi, and 10 minutes of cool down.

Also known as: Stretch exercise, Strengthening exercise, Balance training

Comprehensive training

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 60 or older;
• With a diagnosis of sarcopenia \[defined as EWGSOP-2\] (6);
• Without planned exercise program or unplanned admission in 6 months;
• Could tolerate tests of muscle power and strength.

You may not qualify if:

• Uncontrolled diabetes mellitus;
• Uncontrolled cardiovascular diseases;
• Uncontrolled hypertension;
• Knee or hip prosthesis, pacemaker, fracture in the previous 6 months,
• Critical cognitive (MMSE\<23)
• Mini Nutritional Assessment (MNA \<17)
• Physical dysfunctions that could not tolerate our tests

Sponsors & Collaborators

• China Medical University Hospital: lead

Study Sites (1)

China Medical University Hospital

Taichung, Taiwan

Location

MeSH Terms

Interventions

Tai Ji; IPS e.max Press; Plyometric Exercise

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Exercise Movement Techniques; Physical Therapy Modalities; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• China Medicine University China Medicine University

  China Medicine University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 14, 2021
• First Posted: December 6, 2021
• Study Start: December 1, 2021
• Primary Completion: April 29, 2022
• Study Completion: September 28, 2022
• Last Updated: January 19, 2023

Record last verified: 2023-01

Locations

TW (1)