NCT05141201

Brief Summary

To collect information on and evaluate the long-term safety and effectiveness of Anifrolumab in patients with systemic lupus erythematosus in the real-world post-marketing setting.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,620

participants targeted

Target at P75+ for all trials

Timeline
11mo left

Started Dec 2021

Longer than P75 for all trials

Geographic Reach
1 country

47 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress83%
Dec 2021Mar 2027

First Submitted

Initial submission to the registry

November 19, 2021

Completed
13 days until next milestone

First Posted

Study publicly available on registry

December 2, 2021

Completed
19 days until next milestone

Study Start

First participant enrolled

December 21, 2021

Completed
5.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 31, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2027

Last Updated

March 19, 2026

Status Verified

March 1, 2026

Enrollment Period

5.3 years

First QC Date

November 19, 2021

Last Update Submit

March 17, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Incidence of ADRs

    Incidence of ADRs related to Anifrolimab. Safety specification: Herpes zoster, serious infections, anaphylaxis, malignancy and reactivation of hepatitis B virus

    from the baseline to 52 weeks

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

patients with systemic lupus erythematosus insufficiently responding to currently available treatment

You may qualify if:

  • patients with systemic lupus erythematosus insufficiently responding to currently available treatment -

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (47)

Research Site

Aichi, Japan

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Akita, Japan

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Aomori, Japan

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Chiba, Japan

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Ehime, Japan

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Fukui, Japan

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Fukuoka, Japan

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Fukushima, Japan

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Gifu, Japan

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Gunma, Japan

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Hiroshima, Japan

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Hokkaido, Japan

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Hyōgo, Japan

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Ibaraki, Japan

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Ishikawa, Japan

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Kagawa, Japan

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Kagoshima, Japan

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Kanagawa, Japan

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Kochi, Japan

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Kumamoto, Japan

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Kyoto, Japan

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Mie, Japan

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Miyagi, Japan

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Miyazaki, Japan

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Nagano, Japan

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Nagasaki, Japan

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Nara, Japan

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Niigata, Japan

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Numakunai, Japan

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Okayama, Japan

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Okinawa, Japan

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Osaka, Japan

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Ōita, Japan

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Saga, Japan

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Saitama, Japan

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Shiga, Japan

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Shimane, Japan

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Shizuoka, Japan

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Tochigi, Japan

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Tokushima, Japan

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Tokyo, Japan

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Tottori, Japan

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Toyama, Japan

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Wakayama, Japan

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Yamagata, Japan

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Yamaguchi, Japan

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Yamanashi, Japan

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MeSH Terms

Conditions

Lupus Erythematosus, Systemic

Condition Hierarchy (Ancestors)

Connective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 19, 2021

First Posted

December 2, 2021

Study Start

December 21, 2021

Primary Completion (Estimated)

March 31, 2027

Study Completion (Estimated)

March 31, 2027

Last Updated

March 19, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluatedas per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. Yes,indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.

Time Frame
AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
Access Criteria
When a request has been approved AstraZeneca will provide access to the de-identified individual patient-level datain an approved sponsored tool . Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information.Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access.For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
More information

Locations