Emotion and Cognitive Function and Brain Imaging Change in HD Patients

NCT05137470 | Unknown

• 1 other identifier: YYYXYJ-2021-275
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

1. 1.Observe the influence of entering hemodialysis treatment on the emotional and cognitive functions of ESRD patients.
2. 2.Observe the influence of entering hemodialysis treatment on the brain structure imaging of ESRD patients.
3. 3.Analyze and study the relevant clinical risk factors of the above-mentioned effects, and find targets for therapeutic intervention.

Conditions

Kidney Failure, Chronic; Cognitive Dysfunction; Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

• Appears obvious emotional and cognitive decline, or abnormal head MRI

  Appears obvious emotional and cognitive decline, or abnormal head MRI

  2 years

Study Arms (2)

Newly HD patients

Newly admitted patients with uremia who started hemodialysis treatment

Other: This is an observational study

MHD patients

Maintenance hemodialysis patients

Other: This is an observational study

Interventions

This is an observational study OTHER

This is an observational study

MHD patients; Newly HD patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Uremia patients undergoing hemodialysis treatment in the hemodialysis room of Beijing Friendship Hospital

You may qualify if:

• Patients who are new to hemodialysis treatment, and those who are on regular hemodialysis treatment for ≥6 months.
• Age ≥ 18 years old.

You may not qualify if:

• There was already a severe central nervous system disease before dialysis.
• Hearing and visual impairment cannot communicate or cooperate.
• Mental illness and incapacity.
• The magnetic resonance examination could not be completed for various reasons.
• Life expectancy with serious diseases is less than 6 months.

Sponsors & Collaborators

• Beijing Friendship Hospital: lead

Study Sites (1)

Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, 100050, China

RECRUITING

MeSH Terms

Conditions

Kidney Failure, Chronic; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• WENHU LIU, doctor

  Beijing Friendship Hospital

  STUDY DIRECTOR

Central Study Contacts

XU LIU, master

CONTACT

+86-010-63138579; liuxu_000@sina.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 24, 2021
• First Posted: November 30, 2021
• Study Start: October 1, 2021
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: November 30, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)