Cardiac Autonomic Modulation in Older Hypertensive Individuals Submitted to Different Types of Physical Training

NCT05135247 | Completed

• 1 other identifier: 1.092.824
• Study Type: interventional
• Target: 61
• Locations: 0 countries
• Sites: N/A

Brief Summary

Sixty-one sedentary older hypertensive individuals were randomized to four groups: continuous aerobic training (CA), interval aerobic training (IA), resistance training (R), and control (C) group. The protocol included 3 sessions of training by week for 12 weeks. C individuals were instructed to continue their usual activities. They were submitted to the passive tilt test before and after the research protocol, evaluating the heart rate (HR), low frequency (LF) and high frequency (HF) bands, detrended fluctuation analysis (DFAα1) and entropy

Conditions

Autonomic Dysfunction

Keywords

older individuals; heart rate variability; physical training; hypertension

Outcome Measures

Primary Outcomes (5)

• Heart rate

  Heart rate was obtained before and after the protocol by electrocardiogram, performed before and after tilt test at each time.

  12 weeks

• Low frequency band

  Low frequency band was obtained before and after the protocol by electrocardiogram, performed before and after tilt test at each time.The electrical signal from the electrocardiogram was filtered and amplified. The amplified signals were processed by ananalog-digital converter (DI-720, DATAQ Instruments, Akron, OH, USA) and sampled (1000 hz per channel) by a computer program (Windaq, DATAQ, Akron, OH, USA) installed in an IBM/PC computer.

  12 weeks

• High frequency band

  High frequency band was obtained before and after the protocol by electrocardiogram, performed before and after tilt test at each time.The electrical signal from the electrocardiogram was filtered and amplified. The amplified signals were processed by ananalog-digital converter (DI-720, DATAQ Instruments, Akron, OH, USA) and sampled (1000 hz per channel) by a computer program (Windaq, DATAQ, Akron, OH, USA) installed in an IBM/PC computer.

  12 weeks

• Entropy

  Entropy was obtained before and after the protocol by electrocardiogram, performed before and after tilt test at each time.The electrical signal from the electrocardiogram was filtered and amplified. The amplified signals were processed by ananalog-digital converter (DI-720, DATAQ Instruments, Akron, OH, USA) and sampled (1000 hz per channel) by a computer program (Windaq, DATAQ, Akron, OH, USA) installed in an IBM/PC computer.

  12 weeks

• Short term detrended fluctuation analysis

  Short term detrended fluctuation analysis obtained before and after the protocol by electrocardiogram, performed before and after tilt test at each time.The electrical signal from the electrocardiogram was filtered and amplified. The amplified signals were processed by ananalog-digital converter (DI-720, DATAQ Instruments, Akron, OH, USA) and sampled (1000 hz per channel) by a computer program (Windaq, DATAQ, Akron, OH, USA) installed in an IBM/PC computer.

  12 weeks

Study Arms (4)

continuous aerobic training (CA)

EXPERIMENTAL

The CA group was trained with 70% of maximum heart rate (MHR) for 30 minutes.

Other: Exercise

resistance training (R)

EXPERIMENTAL

The R sessions consisted of a set of each proposed exercise: sitting bench press, legpress, back row, leg extension, shoulders high pull, seated leg curl, biceps curls, standing calf, triceps in the pulley, and abdominal crunches, with 8 - 10 repetitions with 75% 1MR.

Other: Exercise

interval aerobic training (IA)

EXPERIMENTAL

The IA group was submitted to exercise intensities of 60% for 2 minutes and 80% for 2 minutes, alternately, with a total of 30 minutes.

Other: Exercise

control (C)

NO INTERVENTION

Individuals in the control group maintained their usual activities.

Interventions

Exercise OTHER

3 different types of training or control

continuous aerobic training (CA); interval aerobic training (IA); resistance training (R)

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• Positive treadmill test (TT) for ischemia
• Related left ventricular systolic dysfunction of any degree
• Presence of arrhythmias
• Use of β-blockers
• Use more than seven doses of ethyl alcohol per week
• Renal insufficiency
• Diabetes
• Hyper- or hypothyroidism
• Limiting lung disease
• Osteomioarticular impairment that would limit exercise performance
• SBP ≥160 and/or DBP ≥ 100 mmHg on baseline

Sponsors & Collaborators

• University of Sao Paulo: lead

MeSH Terms

Conditions

Primary Dysautonomias; Hypertension

Interventions

Exercise

Condition Hierarchy (Ancestors)

Autonomic Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associated Professor

Model Details: The individuals were randomized into four groups: continuous aerobic training (CA), interval aerobic training (IA), resistance training (R), and control (C), which performed physical exercises three times a week for twelve weeks, with a total of 36 sessions. The tilt test was performed before and after the research protocol. Individuals in the control group were only encouraged to maintain their usual activities.

Study Record Dates

• First Submitted: November 9, 2021
• First Posted: November 26, 2021
• Study Start: January 10, 2015
• Primary Completion: June 10, 2017
• Study Completion: July 10, 2017
• Last Updated: November 26, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Data will be made available after the publication of the study, with no time to end sharing
• Access Criteria: contact with the main researcher