Developing a Physiological Understanding of High Duration Activity

NCT05135234 | Unknown

• 2 other identifiers: 15463-01University of Houston
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

When muscles are not contracting, the local energy demand by muscle and use of specific fuels used to produce energy by oxidative metabolism are minimal. The time people spend sitting inactive (sedentary time) typically comprises more than half of the day. This sedentary behavior is associated with elevated risk of diabetes, cardiovascular diseases, some cancers, and multiple conditions leading to poor aging. From a progressive series of experiments, the driving goal is to develop a physiological method for sustaining contractile activity via oxidative metabolism over more time than is possible by traditional exercise (hours, not minutes per day). Developing a physiological method suitable of prolonged muscular activity for ordinary people (who are often unfit) requires gaining fundamental insights about muscle biology and biomechanics. This also entails a careful appreciation of the ability to isolate specific muscles in the leg during controlled movements, such as the soleus muscle during isolated plantarflexion. This includes quantifying specific biological processes that are directly responsive to elevated skeletal muscle recruitment. The investigators will focus on movement that is safe and practical for ordinary people to do given their high amount of daily sitting time. This includes developing methods to optimally raise muscle contractile activity, in a way that is not limited by fatigue, and is feasible throughout as many minutes of the day as possible safely. This also requires development of methodologies to quantify specific muscular activity, rather than generalized body movement. There is a need to learn how much people can increase muscle metabolism by physical activity that is perceived to them as being light effort. It is important to learn if this impacts systemic metabolic processes under experimental conditions over a short term time span in order to avoid confounding influences of changes in body weight or other factors.

Conditions

Sedentary Lifestyle; Hyperinsulinemia; Glucose Tolerance Impaired; Low-density-lipoprotein-type; Aging Problems; Lipid Metabolism Disorders; Inactivity, Physical; Metabolic Disorder, Glucose

Keywords

sedentary; physical activity; muscle contractile activity

Outcome Measures

Primary Outcomes (6)

• Oxygen cost of isolated muscle contractions

  The energetics of isolated muscle contractions will be described relative to the distinct biomechanics of different types of muscular movement

  Acute contractile activity (at least 3 minutes)

• Fatigue time during muscle group specific contractile activity

  Determinants of muscular endurance as a function of recruitment intensity

  Acute measurements less than 1 day. The exact duration is an individual response that is an outcome of unknown minutes consistent with the fatiguability of different movements.

• Change in postprandial glucose regulation

  Glucose concentration response during the postprandial period after an oral glucose tolerance test

  The change through the completion of the postprandial period, an average of 180 minutes

• Change in very low density lipoprotein (VLDL) - Triglyceride

  The concentration of triglyceride in the plasma VLDL lipoprotein

  The change through the completion of an acute fasting period, approximately 8-12 hours

• The change in muscular inactivity time as a result of isolated contractile activity of the soleus

  Development of an objective method(s) to quantify sedentary vs. non sedentary time.

  Throughout the waking day (~16 hours).

• Angiopoietin-like protein 4

  One of the molecular determinants of lipoprotein lipase regulation

  The acute time course during the onset of muscular inactivity and contractile activity within 30 minutes to 8 hours

Secondary Outcomes (12)

• Recruited mass of the soleus and other muscles in the triceps surae during isolated plantarflexion

  During acute contractile activity of at least 3 minutes

• Electrical activity of muscle, Electromyography (EMG)

  At least 3 minute recording periods

• Local rate of oxygen consumption of working muscle

  Steady-state measurements taken for ~6 continuous minutes of contractile activity

• The ratio of carbohydrate vs. fat oxidation

  Acute responses within less than 24 hours.

• Plasma insulin change

  The change through the completion of the postprandial period, an average of 180 minutes

Study Arms (1)

Muscular Exercise

EXPERIMENTAL

Increased level of low effort muscular activity

Behavioral: Muscular Exercise

Interventions

Muscular Exercise BEHAVIORAL

Sedentary time (muscular inactivity when sitting) will be replaced with low effort muscular activity

Muscular Exercise

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age must be 18 years or older
• Able to fast overnight
• Can maintain diet, medications, and sleep habits between each of the testing visits.
• Lifestyle is consistent with participation in a study evaluating reductions of inactivity (defined by sitting at a low metabolic rate because of minimal muscular activity)
• Willing and able to wear small wearable activity monitors under their clothes as instructed.
• No plans to start a new diet or exercise program if enrolled in the present study.

You may not qualify if:

• Practical barriers to completing the study, such as plans to move, or work, or family commitments.
• Plans to change lifestyle during the present study.
• Have physical, vocational, or reasons that prohibit ordinary sitting behaviors present in the modern world.
• Currently dieting to change body weight, or have eating disorder.
• Are pregnant or plan to become pregnant.
• Taking medications that affect bleeding (ie anticoagulants).
• Allergy to lidocaine excludes biopsy component of study.

Sponsors & Collaborators

• University of Houston: lead
• American Diabetes Association: collaborator

Study Sites (1)

University of Houston

Houston, Texas, 77204, United States

Location

MeSH Terms

Conditions

Sedentary Behavior; Hyperinsulinism; Glucose Intolerance; Lipid Metabolism Disorders; Glucose Metabolism Disorders; Motor Activity

Condition Hierarchy (Ancestors)

Behavior; Metabolic Diseases; Nutritional and Metabolic Diseases; Hyperglycemia

Study Officials

• Marc T Hamilton, Ph.D.

  University of Houston

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 16, 2019
• First Posted: November 26, 2021
• Study Start: August 1, 2016
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: May 19, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)