Coronavirus Pediatric Serological Study

NCT05128435 | Completed

• 1 other identifier: 200629
• Study Type: observational
• Target: 49
• Locations: 1 country
• Sites: 1

Brief Summary

The Coronavirus Pediatric Serological Study's aim is to provide a better insight of children's immune response after SARS-CoV-2 infection. Serological tests were conducted on blood samples taken 3 to 5 months after the children's viral infection. The study was performed in collaboration with the Institute of Medical Immunology, were antibody levels were measured and immunoglobulin subclasses profiles were studied.

Conditions

SARS-CoV2 Infection

Keywords

SARS-CoV-2; Immune response; Children

Outcome Measures

Primary Outcomes (3)

• SARS-CoV-2 antibody levels in asymptomatic patients

  Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children who did not show any symptoms at the time of the viral infection

  3 to 5 months after SARS-CoV-2 infection

• SARS-CoV-2 antibody levels in mildly symptomatic patients

  Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children presenting mild symptoms at the time of the viral infection

  3 to 5 months after SARS-CoV-2 infection

• SARS-CoV-2 antibody levels in hospitalized patients

  Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children who required an hospitalisation at the time of the viral infection

  3 to 5 months after SARS-CoV-2 infection

Study Arms (1)

Positive Children

Children under 15 years old tested positive for SARS-CoV-2 by PCR on nasopharyngeal swab

Diagnostic Test: Blood sample

Interventions

Blood sample DIAGNOSTIC_TEST

Blood sample taken 3 to 5 months after the infection

Positive Children

Eligibility Criteria

• Age: 0 Months - 179 Months
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Children under 15 years old

You may qualify if:

• \- Tested positive for SARS-CoV-2 by PCR on naso-pharyngeal swab performed in Saint-Pierre Hospital (Brussels) between March 1 2020 and December 31 2020

Sponsors & Collaborators

• Centre Hospitalier Universitaire Saint Pierre: lead

Study Sites (1)

Saint-Pierre Hospital

Brussels, 1000, Belgium

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood samples

MeSH Terms

Conditions

COVID-19

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor (pediatrician)

Study Record Dates

• First Submitted: October 28, 2021
• First Posted: November 22, 2021
• Study Start: March 1, 2020
• Primary Completion: December 31, 2020
• Study Completion: May 31, 2021
• Last Updated: November 22, 2021

Record last verified: 2021-11

Locations

BE (1)