SARS-CoV-2 Transmission in Belgian Primary Schools of the Federation Wallonia - Brussels: An Epidemiological Pilot Study

NCT05046470 | Active Not Recruiting

• 2 other identifiers: 2020/16NOV/552ISRCTN16837012
• Study Type: observational
• Target: 1,233
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators hypothesize that children are less likely to become infected in the school environment, compared to the household or outside the school setting. Primary schools do not play a major role in SARS-CoV-2 spreading. They hypothesize that incidence level in schools is mainly a consequence of community transmission. The incidence level in household and that the secondary attack rate in schools remains at least 5 times lower that the transmission level in households.

Conditions

SARS-CoV-2 Infection

Keywords

Primary Schools

Outcome Measures

Primary Outcomes (4)

• Infection of a child with SARS-CoV-2 secondary to a classmate

  Time varying number and proportion of children infected with SARS-CoV-2 secondary to an asymptomatic infected classmate (transmission rate inside school with the child being the infector).

  6 weeks

• Infection of an adult school-attender with SARS-CoV-2 secondary to an infected child

  Time varying number and proportion of adult school-attenders infected with SARS-CoV-2 secondary to an asymptomatic infected child (transmission rate inside school but from a child to an adult).

  6 weeks

• Infection of a child with SARS-CoV-2 secondary to an adult school attender

  Time varying number and proportion of children infected with SARS-CoV-2 secondary to an infected adult school-attender (transmission rate inside school but from an adult to a child)

  6 weeks

• Infection of a child with SARS-CoV-2 secondary to a contact outside the school, including the household

  Time varying number and proportion of children infected with SARS-CoV-2 secondary to a household contact or outside the school (transmission rate from in community).

  6 weeks

Eligibility Criteria

• Age: 6 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All Belgian primary schools of the Federation Wallonia - Brussels that have organized a full resumption of school activities with the control measures recommended by the government, are eligible for the study. Twelve schools were chosen by purposive criteria: either high (≥2 classes per grade) or low size of the school, a school within an area with either a high or a low incidence of SARS-CoV-2 during April 2020, the first wave of covid-19 in Belgium, and a school with either a high or a low socioeconomic level (Belgian 20-point-scale ISE idex \>14 or \<6).

You may qualify if:

• All children and school attenders from selected schools was invited to participate

You may not qualify if:

• Refusal to provide written informed consent before enrolment

Sponsors & Collaborators

• Université Catholique de Louvain: lead
• University of Liege: collaborator
• Université Libre de Bruxelles: collaborator

Study Sites (1)

UCLouvain

Brussels, 1200, Belgium

Location

Related Links

• Protocol
• Study website

Biospecimen

Retention: SAMPLES WITH DNA

Saliva samples

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Annie Robert, Pr

  Université Catholique de Louvain

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 7, 2021
• First Posted: September 16, 2021
• Study Start: January 14, 2021
• Primary Completion: January 14, 2023
• Study Completion: January 14, 2025
• Last Updated: May 8, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)