NCT05127993

Brief Summary

The passive Talaris Demonstrator (TD) is developed in continuation of previous prototypes. The main goal of the experiment is to evaluate the effectiveness of TD during daily activities.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
8

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2021

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 21, 2021

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

October 4, 2021

Completed
2 months until next milestone

First Posted

Study publicly available on registry

November 19, 2021

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 17, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 17, 2022

Completed
Last Updated

April 29, 2022

Status Verified

April 1, 2022

Enrollment Period

1.2 years

First QC Date

October 4, 2021

Last Update Submit

April 28, 2022

Conditions

Outcome Measures

Primary Outcomes (7)

  • Performance

    Heart rate during all tasks

    Through study completion, a period of 4 months

  • Performance

    Time needed to perform the L-test

    Through study completion, a period of 4 months

  • Performance

    Speed during 6 minutes walk test

    Through study completion, a period of 4 months

  • Physiological

    Electromyography: lower limb muscle activity during different movements (% of the MVC)

    Through study completion, a period of 4 months

  • Physiological

    Oxygen consumption during stair climbing, slope walking and during the 6 minutes walk test

    Through study completion, a period of 4 months

  • Psychological

    Visual analogue scale for comfort (score: 0= not comfortable, 100 = comfortable) and fatigue (score: 0= not fatiguing, 100 = fatiguing) during all tasks

    Through study completion, a period of 4 months

  • Biomechanical

    Joint angels and joint angular velocities of hip, knee and ankle joints

    Through study completion, a period of 4 months

Study Arms (2)

Novel prosthesis

EXPERIMENTAL

A unilateral transtibial amputee will conduct experiments with the novel prosthesis followed by experiments with the current prosthesis.

Device: Passive Talaris Demonstrator

Current prosthesis

ACTIVE COMPARATOR

A unilateral transtibial amputee will conduct experiments with the current prosthesis followed by experiments with the novel prosthesis.

Device: Passive Talaris Demonstrator

Interventions

The amputee will walk with the passive Talaris Demonstrator, a novel prosthetic foot, designed and built by "Axiles Bionics".

Current prosthesisNovel prosthesis

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Unilateral transtibial (below knee) amputation
  • Unilateral transfemoral (above knee) amputation
  • Healthy subject
  • Medicare Functional Classification Level: K2-4

You may not qualify if:

  • Any neurological disease
  • Upper limb or bilateral amputation
  • Stump pain or bad fit of the socket

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Vrije Universiteit Brussel

Brussels, 1050, Belgium

Location

MeSH Terms

Conditions

Wounds and Injuries

Study Officials

  • Kevin De Pauw

    Vrije Universiteit Brussel

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Prof. Dr.

Study Record Dates

First Submitted

October 4, 2021

First Posted

November 19, 2021

Study Start

January 21, 2021

Primary Completion

March 17, 2022

Study Completion

March 17, 2022

Last Updated

April 29, 2022

Record last verified: 2022-04

Locations