The Effect Of Anaerobic Exercise On Bone Morphogenetic Protein 9

NCT05117437 | Unknown

• 1 other identifier: TDK-2020-22186
• Study Type: observational
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

Bone morphogenetic protein (BMP) 9 from the BMP family has an important role in the remodeling of bone and cartilage. Due to these features, BMP9 can play an important role in especially anaerobic exercise training adaptations. However, the role of anaerobic exercise in these effects is still unclear. The aim of this study is to investigate the role of BMP9 on the effects of acute and chronic anaerobic exercise on bone metabolism markers. Postprandial venous blood samples were taken pre- and post- acute YOYO intermittent recovery test (level 1) in 40 trained male athletes aged 18-35 who did anaerobic sports (such as basketball, volleyball and handball) and 41 sedentary volunteers aged 18-35. Serum BMP9, as markers of bone formation and resorption; alkaline phosphatase (ALP), C-terminal telopeptide of type 1 collagen (CTX1), cartilage oligomeric matrix protein (COMP) and calcium levels were determined. The data to be obtained as a result of our study can give information about the relationship between the skeletal and bone health of the athletes and anaerobic exercise.

Conditions

Healthy; Exercise

Keywords

Bone morphogenetic protein; BMP9; anaerobic exercise

Outcome Measures

Primary Outcomes (3)

• Change from serum BMP9 levels at pre- and post- YOYO intermittent test

  Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum Bone morphogenetic protein 9 (BMP9) was determined.

  between 40-50 minutes

• Change from serum CTX1 levels at pre- and post- YOYO intermittent test

  Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum C-terminal telopeptide of Type 1 collagen (CTX1) was determined.

  between 40-50 minutes

• Change from serum COMP levels at pre- and post- YOYO intermittent test

  Postprandial venous blood samples were obtained before and after acute YOYO IR test (level 1). The YOYO test lasted 10-20 minutes depending on the ability level of the participants. A blood sample was taken 15 minutes before and 15 minutes after the YOYO test. From these blood samples, serum cartilage oligomeric matrix protein (COMP) was determined.

  between 40-50 minutes

Study Arms (2)

Athletic group

Healthy male athletes who have been doing regular anaerobic sports (such as basketball, volleyball and handball) for at least 3 months

Other: Physiological test; Other: Physical test; Other: Biochemical tests

Control group

Healthy sedentary (not doing regular sports for at least 3 months) men with age and physical characteristics similar to the athlete group

Other: Physiological test; Other: Physical test; Other: Biochemical tests

Interventions

Physiological test OTHER

This test was conducted to determine the endurance levels of the participants.

Also known as: YOYO intermittent recovery test (level 1)

Athletic group; Control group

Physical test OTHER

Height, weight, and BMI were determined

Athletic group; Control group

Biochemical tests OTHER

BMP9, CTX1, COMP, oxLDL protein levels, ALP, GGT, TAS, TOS, OSI, NO, calcium, T-C, LDL-C, Triglyceride, HDL-C, glucose, CRP, AST, ALT, erythrocyte, mean erythrocyte volume (MCV), hematocrit, leukocyte, thrombocyte levels were determined from blood samples.

Athletic group; Control group

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Athletic group: trained male athletes who did anaerobic sports (such as basketball, volleyball and handball) Control group: sedentary males

You may qualify if:

• being male
• having a body mass index of less than 30 being

You may not qualify if:

• to have some disease or disability
• to regularly use cigarettes and alcohol
• to use any medication or antioxidant substance

Sponsors & Collaborators

• Ege University: lead

Study Sites (1)

Ege University Faculty of Sport Sciences

Izmir, 35040, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise Test

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Ergometry; Investigative Techniques

Study Officials

• Faruk Turgay

  Ege University Faculty of Sport Sciences

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: October 11, 2021
• First Posted: November 11, 2021
• Study Start: December 3, 2020
• Primary Completion: June 1, 2021
• Study Completion: December 1, 2021
• Last Updated: November 11, 2021

Record last verified: 2021-11

Locations

TU (1)