Tango for Neuropathy Among Breast Cancer Survivors

NCT05114005 | Completed Results DMC

• 4 other identifiers: 2015C0090NCI-2018-00310R21AG068831OSU-15047
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

Group dance classes have been found to improve markers of quality of life and physical health (i.e., balance) among some populations engaged in rehabilitation, such as the elderly and individuals with Parkinson Disease. However, such interventions have yet to be studied among cancer survivors despite the relevance of quality of life and physical health within cancer survivorship. Group dance classes are a promising avenue in that they deliver activity-based medicine in a social context, thus potentially improving physical as well as psychosocial aspects of health. To further this avenue of inquiry, we propose to study the effect of dance-based interventions for cancer survivors.

Conditions

Cancer, Breast; Neuropathy

Outcome Measures

Primary Outcomes (2)

• Postural Control (Variability)

  root-mean square of the center of pressure (COP)

  At baseline, week 8 of intervention, and at 4 week follow-up post intervention

• Intrinsic Motivation

  Intrinsic motivation will be measured using a subscale of the Intrinsic Motivation Inventory (IMI). The 6 item Interest/Enjoyment subscale of the IMI represents intrinsic motivation in an activity just performed as a possible score of 6 to 36 with 6 = most; 18 = neutral; 36 = least interesting/enjoyable. Specific items queried include whether the activity just performed was: enjoyable, enjoyed, boring (reverse order), interesting, fun, and able to hold the participant's attention.

  Assessed at week 4, week 8, and week 12

Secondary Outcomes (19)

• Postural Control (Ellipse Area)

  At baseline, week 8 of intervention, and at 4 week follow-up post intervention

• Postural Control (Velocity)

  At baseline, week 8 of intervention, and at 4 week follow-up post intervention

• Postural Control (Complexity)

  At baseline, week 8 of intervention, and at 4 week follow-up post intervention

• Postural Control (Variability) at Tango Sessions

  at the beginning and at the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks

• Postural Control (Ellipse Area) at Tango Sessions

  at the beginning and at the end of each assessment or intervention session for up to 20 sessions, up to 8 weeks

Other Outcomes (2)

• Quantified Clinical Measure of Balance Function

  8 weeks

• Quantified Clinical Measure of Balance Function

  1 month follow-up post-intervention

Study Arms (2)

Tango

EXPERIMENTAL

The intervention will consist of 16 Argentine Tango (Tango) sessions, adapted for neurorehabilitation per Hackney and Earhart (2010). Delivered over 8 weeks at a frequency of 2x per week and duration of 1 hour per session, this program teaches the basics steps of partnered Tango dance.

Behavioral: Rhythmic Auditory Stimulation

Home Exercise (HEX)

ACTIVE COMPARATOR

The control group will consist of an evidence-based, structured home exercise program (HEX) based on the 8 week intervention described by Zimmer et al (2018) and recommended by physical therapists specializing in BC within our organization. This program consists of information on neuropathy and fall prevention combined with a schedule of 1 hour training (i.e., endurance, resistance, and sensorimotor) performed 2x per week

Behavioral: Evidence-Based Exercise

Interventions

Rhythmic Auditory Stimulation BEHAVIORAL

Rhythmically-entrained sensorimotor activity.

Tango

Evidence-Based Exercise BEHAVIORAL

This program consists of information on neuropathy and fall prevention combined with a schedule of 1 hour training (i.e., endurance, resistance, and sensorimotor) performed 2x per week

Home Exercise (HEX)

Eligibility Criteria

• Age: 40 Years+
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Breast cancer survivor stage I-III
• Symptomatic for neuropathy
• postural control outside 70% CI for adults who are middle-aged without neurotrauma
• having completed taxane-based chemotherapy treatment at least 3 months ago;
• able to understand and comply with directions associated with testing and study treatments.

You may not qualify if:

• Pre-existing vestibular deficit;
• poorly controlled diabetes (hgA1C \> 8);
• non-ambulatory or lower extremity amputation (assistive devices allowed);
• use of cytotoxic or immunotherapy during study (endocrine therapy allowed);
• participation in physical therapy during the study;
• contraindication to participate in Tango due to orthopedic issue (e.g., herniated vertebral disc);

Sponsors & Collaborators

• Ohio State University Comprehensive Cancer Center: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

Stephanie Spielman Comprehensive Breast Center

Columbus, Ohio, 43212, United States

Location

Related Publications (5)

• Hackney ME, Earhart GM. Recommendations for Implementing Tango Classes for Persons with Parkinson Disease. Am J Dance Ther. 2010 Jun;32(1):41-52. doi: 10.1007/s10465-010-9086-y.

  PMID: 30369677 BACKGROUND

• Zimmer P, Trebing S, Timmers-Trebing U, Schenk A, Paust R, Bloch W, Rudolph R, Streckmann F, Baumann FT. Eight-week, multimodal exercise counteracts a progress of chemotherapy-induced peripheral neuropathy and improves balance and strength in metastasized colorectal cancer patients: a randomized controlled trial. Support Care Cancer. 2018 Feb;26(2):615-624. doi: 10.1007/s00520-017-3875-5. Epub 2017 Sep 30.

  PMID: 28963591 BACKGROUND

• Worthen-Chaudhari L, Schnell PM, Hackney ME, Lustberg MB. Partnered dance evokes greater intrinsic motivation than home exercise as therapeutic activity for chemotherapy-induced deficits: secondary results of a randomized, controlled clinical trial. Front Psychol. 2024 Jun 19;15:1383143. doi: 10.3389/fpsyg.2024.1383143. eCollection 2024.

  PMID: 38962217 DERIVED

• Lantis K, Schnell P, Bland CR, Wilder J, Hock K, Vargo C, Glover NA, Hackney ME, Lustberg MB, Worthen-Chaudhari L. Biomechanical effect of neurologic dance training (NDT) for breast cancer survivors with chemotherapy-induced neuropathy: study protocol for a randomized controlled trial and preliminary baseline data. Trials. 2023 Sep 1;24(1):564. doi: 10.1186/s13063-023-07554-z.

  PMID: 37658464 DERIVED

• Lantis KD, Schne P, Bland CR, Wilder J, Hock K, Glover NA, Hackney ME, Lustberg MB, Worthen-Chaudhari L. Biomechanical effect of neurologic dance training (NDT) for breast cancer survivors with chemotherapy-induced neuropathy: study protocol for a randomized controlled trail and preliminary baseline data. Res Sq [Preprint]. 2023 Jun 29:rs.3.rs-2988661. doi: 10.21203/rs.3.rs-2988661/v1.

  PMID: 37461666 DERIVED

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Results Point of Contact

• Title: Dr. Lise Worthen-Chaudhari
• Organization: The Ohio State University Comprehensive Cancer Center

wort08@osumc.edu

614-293-6281

Study Officials

• Lise Worthen-Chaudhari, PhD, MFA

  Ohio State University Comprehensive Cancer Center

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Scientist

Study Record Dates

• First Submitted: September 20, 2021
• First Posted: November 9, 2021
• Study Start: August 15, 2021
• Primary Completion: April 15, 2024
• Study Completion: April 15, 2024
• Last Updated: September 15, 2025
• Results First Posted: September 15, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)