Surgical Treatment of Hepatic Hydatidosis in Elderly Patients

NCT05113550 | Completed

• 1 other identifier: HUB-2021-01
• Study Type: observational
• Target: 279
• Locations: 1 country
• Sites: 2

Brief Summary

Cystic echinococcosis is a clinically complex chronic parasitic disease and a major socioeconomic problem in endemic areas. The safety of liver resection in elderly patients is often debated among medical professionals. The investigators analyzed the postoperative morbidity and mortality rates of elderly patients who underwent surgery at our unit.

Conditions

Cystic Echinococcosis

Outcome Measures

Primary Outcomes (1)

• Morbidity

  Patients with postoperative morbidity according to the Clavien-Dindo score 19, "severe complication" (Clavien-Dindo ≥ IIIa) and postoperative mortality

  90 days

Study Arms (2)

Young group

patients \< 70 years of age

Other: Surgical remove

Elderly

Patients ≥ 70 years of age)

Other: Surgical remove

Interventions

Surgical remove OTHER

liver hydatid cyst (LHC) treated by total or partial pericystectomy

Elderly; Young group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with liver hydatidosis carried out at our Hepato-Pancreato-Biliary Surgery Unit

You may qualify if:

• liver hydatid cyst (LHC)
• pathological diagnosis after surgery
• LHC treated by total or partial pericystectomy

You may not qualify if:

• emergency surgery and simple drainage of cyst

Sponsors & Collaborators

• Universidad de Extremadura: lead

Study Sites (2)

Universidad de Extremadura- Facultad de Medicina

Badajoz, 06080, Spain

Location

Gerardo Blanco-Fernández

Badajoz, 08080, Spain

Location

Related Publications (5)

• Mihmanli M, Idiz UO, Kaya C, Demir U, Bostanci O, Omeroglu S, Bozkurt E. Current status of diagnosis and treatment of hepatic echinococcosis. World J Hepatol. 2016 Oct 8;8(28):1169-1181. doi: 10.4254/wjh.v8.i28.1169.

  PMID: 27729953 BACKGROUND

• Adamina M, Guller U, Weber WP, Oertli D. Propensity scores and the surgeon. Br J Surg. 2006 Apr;93(4):389-94. doi: 10.1002/bjs.5265.

  PMID: 16400708 BACKGROUND

• Jaen-Torrejimeno I, Lopez-Guerra D, Prada-Villaverde A, Blanco-Fernandez G. Pattern of Relapse in Hepatic Hydatidosis: Analysis of 238 Cases in a Single Hospital. J Gastrointest Surg. 2020 Feb;24(2):361-367. doi: 10.1007/s11605-019-04163-7. Epub 2019 Feb 26.

  PMID: 30809783 BACKGROUND

• Jaen-Torrejimeno I, Latorre-Fragua R, Lopez-Guerra D, Rojas-Holguin A, Manuel-Vazquez A, Blanco-Fernandez G, Ramia JM. Jaundice as a clinical presentation in liver hydatidosis increases the risk of postoperative biliary fistula. Langenbecks Arch Surg. 2021 Jun;406(4):1139-1147. doi: 10.1007/s00423-020-02070-z. Epub 2021 Jan 2.

  PMID: 33389115 BACKGROUND

• Muhtarov M, Rainova I, Tamarozzi F. Treatment of Hepatic Cystic Echinococcosis in Patients from the Southeastern Rhodope Region of Bulgaria in 2004-2013: Comparison of Current Practices with Expert Recommendations. Am J Trop Med Hyg. 2016 Apr;94(4):900-5. doi: 10.4269/ajtmh.15-0620. Epub 2016 Feb 1.

  PMID: 26834196 RESULT

MeSH Terms

Conditions

Echinococcosis

Condition Hierarchy (Ancestors)

Cestode Infections; Helminthiasis; Parasitic Diseases; Infections

Study Officials

• Gerardo Blanco-Fernández, MD, PhD

  University of Extremadura

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Profesor

Study Record Dates

• First Submitted: October 28, 2021
• First Posted: November 9, 2021
• Study Start: January 1, 2021
• Primary Completion: September 30, 2021
• Study Completion: September 30, 2021
• Last Updated: November 16, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

ES (2)