Testing the Contribution of Orbitofrontal Cortex Networks to Decision-making

NCT05111223 | Recruiting

• 1 other identifier: STU00216104
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This research study examines the contribution of orbitofrontal cortex (OFC) networks to decision-making.

Conditions

Healthy

Outcome Measures

Primary Outcomes (2)

• Behavior on devaluation task

  Percentage of cues predicting non-devalued vs devalued odors chosen during the devaluation task.

  1 hour after intervention

• Resting-state functional magnetic resonance imaging

  Resting-state activity determined by functional magnetic resonance imaging.

  1 hour after intervention

Study Arms (2)

TMS targeting OFC anterior networks

EXPERIMENTAL

Participants will receive TMS and sham targeting the OFC network.

Device: Real transcranial magnetic stimulation (TMS) before conditioning; Device: Real transcranial magnetic stimulation (TMS) before devaluation test; Device: Sham transcranial magnetic stimulation (TMS)

Experimental: TMS targeting posterior OFC networks

EXPERIMENTAL

Participants will receive TMS and sham targeting the posterior OFC network.

Device: Real transcranial magnetic stimulation (TMS) before conditioning; Device: Real transcranial magnetic stimulation (TMS) before devaluation test; Device: Sham transcranial magnetic stimulation (TMS)

Interventions

Real transcranial magnetic stimulation (TMS) before conditioning DEVICE

Real TMS will be applied using the MagVenture MagPro X100 stimulator with the active side of the Cool-B65 A/P coil before the conditioning phase of the task.

Experimental: TMS targeting posterior OFC networks; TMS targeting OFC anterior networks

Real transcranial magnetic stimulation (TMS) before devaluation test DEVICE

Real TMS will be applied using the MagVenture MagPro X100 stimulator with the active side of the Cool-B65 A/P coil before the devaluation test phase of the task.

Experimental: TMS targeting posterior OFC networks; TMS targeting OFC anterior networks

Sham transcranial magnetic stimulation (TMS) DEVICE

Sham TMS will be applied using the MagVenture MagPro X100 stimulator with the placebo side of the Cool-B65 A/P coil.

Experimental: TMS targeting posterior OFC networks; TMS targeting OFC anterior networks

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18 and 40 years old
• Right-handed
• Fluent English speakers

You may not qualify if:

• History of significant neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.)
• History of major psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, substance use disorder, etc.)
• Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.)
• Significant cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.)
• Current use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.)
• Smell or taste dysfunction
• History of significant allergies requiring hospitalization for treatment
• History of severe asthma requiring hospitalization for treatment
• Habitual smoking
• History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.)
• Dieting or fasting
• Magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.)
• Electronic devices (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.)
• History of metal working without proper eye protection, or injury with metal shrapnel or metal slivers
• Claustrophobia

Sponsors & Collaborators

• Northwestern University: lead

Study Sites (1)

Northwestern University

Chicago, Illinois, 60657, United States

RECRUITING

MeSH Terms

Interventions

Transcranial Magnetic Stimulation

Intervention Hierarchy (Ancestors)

Magnetic Field Therapy; Therapeutics

Study Officials

• Christina Zelano, PhD

  Assistant Professor

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christina Zelano, PhD

CONTACT

312-503-4437; c-zelano@northwestern.edu

Greg Lane, PhD

CONTACT

312-503-7244

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 28, 2021
• First Posted: November 8, 2021
• Study Start: July 12, 2022
• Primary Completion (Estimated): August 31, 2026
• Study Completion (Estimated): August 31, 2026
• Last Updated: August 19, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will share
• Time Frame: Upon publication
• Access Criteria: Data can be obtained from PI for non-profit purposes upon reasonable request

Locations

US (1)