Pilot Study to Validate ex Vivo Expression of Specific Biomarkers of Human Resolutive Macrophages

NCT05106075 | Unknown

• 1 other identifier: 2020/562
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 2

Brief Summary

Human resolutive macrophages are essential immune cells in the resolution of inflammation. This particular type of macrophages remains poorly known and currently there are no biomarkers to identify them in vivo. Within UMR1098-RIGHT, specific biomarkers (secreted molecules and membrane receptors) of human resolutive macrophages (healthy volunteers) have been identified in vitro, but their existence in vivo remains an outstanding issue. An exploratory study (lack of data from the literature) will validate the ex vivo expression of these markers in samples of patients whose inflammation is not, or little, supported by the available therapies (NSAIDs, biotherapies, corticosteroids).

Conditions

Inflammation

Keywords

macrophage; inflammation; inflammation resolution

Outcome Measures

Primary Outcomes (1)

• Quantification of cytokine concentrations in samples by ELISA

  up to 2 months

Study Arms (1)

biologic sample collection

EXPERIMENTAL

Blood samples or gingival exsudat collection

Procedure: blood sample or joint fluid or gingival exudate

Interventions

blood sample or joint fluid or gingival exudate PROCEDURE

blood sample collected by peripheral blood mobilization joint fluid collected by punction gingival exudate collected with paper strips

biologic sample collection

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age Limits (18-80 years)
• Information and non-opposition for participating in the study
• Patients suffering from periodontitis grade III ou IV
• Patients suffering from microcristalline arthritis
• patient with health insurance

You may not qualify if:

• patient under corticotherapy
• pregnancy
• non-compliant patient
• patient with no health insurance
• legal incapacity

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Besancon: lead

Study Sites (2)

CHRU Besançon

Besançon, 25000, France

RECRUITING

Dentist'S Office

Montbéliard, 25200, France

RECRUITING

MeSH Terms

Conditions

Inflammation

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Central Study Contacts

Thomas CHERRIER, MCU-PH

CONTACT

+33(0)768207057; tcherrier@unistra.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: patients are anonymized
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 8, 2021
• First Posted: November 3, 2021
• Study Start: July 7, 2021
• Primary Completion: January 7, 2024
• Study Completion: January 7, 2024
• Last Updated: November 3, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

FR (2)