Imaging Measures of Respiratory Health Registry
iMRH
1 other identifier
observational
1,000
1 country
2
Brief Summary
This is a prospective, observational cohort registry that aims to collect data on pulmonary structure and function in healthy people and those with respiratory disease, using structural and functional pulmonary 1H-MRI and hyperpolarized 129Xe-MRI. Outcome measures generated from MRI may include but are not limited to measures of regional ventilation, pulmonary microarchitecture, and regional gas exchange. Additionally, one of the goals of the registry is to facilitate the development of novel image analysis techniques that have not yet been invented. These data will be stored along with demographic data, clinical data, and pulmonary function testing (PFT) data. This is an open registry. Eligible local and international investigators/institutions can apply for access.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2020
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 11, 2020
CompletedFirst Submitted
Initial submission to the registry
September 27, 2021
CompletedFirst Posted
Study publicly available on registry
November 2, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2045
ExpectedStudy Completion
Last participant's last visit for all outcomes
June 1, 2045
November 2, 2021
October 1, 2021
25 years
September 27, 2021
October 29, 2021
Conditions
Outcome Measures
Primary Outcomes (3)
Structural proton (1H) MRI data
Includes all proton MRI images collected to assess pulmonary structure. Data may be analysed qualitatively and quantitatively.
no predefined schedule in this open registry study; maximum 25 visits, over up to 25 years
Functional proton (1H) MRI data
Includes all proton MRI images collected to assess pulmonary function. Data may be analysed qualitatively and quantitatively.
no predefined schedule in this open registry study; maximum 25 visits, over up to 25 years
Functional hyperpolarized 129-xenon (129Xe) MRI data
Includes all proton images collected to assess pulmonary function. Data may be analysed qualitatively and quantitatively.
no predefined schedule in this open registry study; maximum 25 visits, over up to 25 years
Secondary Outcomes (3)
Resting oxygen saturation
no predefined schedule in this open registry study; maximum 25 visits, over up to 25 years
CFQ-R Respiratory domain
no predefined schedule in this open registry study; maximum 25 visits, over up to 25 years
St. George Respiratory Questionnaire
no predefined schedule in this open registry study; maximum 25 visits, over up to 25 years
Study Arms (2)
Respiratory Disease
Any physician-diagnosed lung disease
Healthy
Healthy control with no physician-diagnosed lung disease
Interventions
Traditional 1H-MRI (room air inhalation) and Xe-129 MRI (requires inhalation of Xenon 129 gas).
Eligibility Criteria
Eligible individuals with respiratory disease will be identified from various Respiratory Medicine or subspecialty clinics at British Columbia Children's Hospital (BCCH) or from analogous clinics at St Paul's Hospital (SPH). Participants may be contacted using a First Contact Letter, or permission to approach will be obtained by a member of their circle of care. Healthy participants will be recruited from family members of patients in the Division of Respiratory Medicine at BCCH and SPH as well as from the community or other clinics using flyers or a First Contact Letter.
You may qualify if:
- Physician-diagnosed lung disease - based on a diagnosis made by a treating staff physician and confirmed by the principal investigator.
- Age 0-99 years.
- Informed consent by participant, parent, or legal guardian
- In the opinion of the Investigator, the participant will likely be able to perform maneuvers to obtain technically acceptable pulmonary XeMRI images.
You may not qualify if:
- Physical findings at screening that, in the opinion of the Investigator, would compromise the safety of the participant or the quality of the research data.
- Requirement of supplementary oxygen to maintain an oxygen saturation above 95%.
- Failed MRI screening form.
- History of claustrophobia.
- Known current pregnancy or lactation.
- Healthy
- Age 0-99 years
- Informed consent by participant, parent, or legal guardian
- In the opinion of the Investigator, the participant will likely be able to perform maneuvers to obtain technically acceptable pulmonary MRI images.
- Physician-diagnosed lung disease.
- Failed MRI screening form.
- History of claustrophobia.
- Physical findings at screening that, in the opinion of the Investigator, would compromise the safety of the participant or the quality of the research data.
- Known current pregnancy or lactation.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
British Columbia Children's Hospital
Vancouver, British Columbia, V6H 3N1, Canada
St. Paul's Hospital
Vancouver, British Columbia, V6Z 1Y6, Canada
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jonathan Rayment, MDCM, MSc
University of British Columbia
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 10 Years
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Clinical Assistant Professor
Study Record Dates
First Submitted
September 27, 2021
First Posted
November 2, 2021
Study Start
June 11, 2020
Primary Completion (Estimated)
June 1, 2045
Study Completion (Estimated)
June 1, 2045
Last Updated
November 2, 2021
Record last verified: 2021-10
Data Sharing
- IPD Sharing
- Will share
- Access Criteria
- Criteria for access to the iMRH-Registry Data: 1. The Proposed Study must demonstrate approval by a Qualified REB 2. The objectives of the Proposed Study must align with the scientific objectives of the iMRH-Registry (see §5) 3. Use of the iMRH Registry Data in the Proposed Study must respect the informed consent given by the participants of the iMRH Registry; 4. The Proposed Study must have scientific merit, as assessed by the iMRH Registry Data Access Committee 5. The User-Investigator must demonstrate sufficient funding to perform the Proposed Study.
iMRH-Registry Data may be shared with investigators from BCCHR/UBC or elsewhere. iMRH-Registry Co-Investigaotrs using iMRH Registry Data to address the Scientific Objectives of the iMRH Registry do not need to formally apply for access. All other User-Investigators (domestic and international) must apply to the iMRH-Registry Data Access Committee for access to the iMRH-Registry Data.