The Effect of Avocado vs. Usual Diet on Skin Aging

NCT05102604 | Completed

• 1 other identifier: 19-001834
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial aims to assess the effect of providing one avocado per day on skin health in comparison with a control group maintaining their habitual diets. Participants will be randomly assigned to one of two equally sized groups. Both groups will be instructed to continue to follow their habitual diet but the intervention group will receive one avocado per day. Participants will be followed for outcomes for a four-month period.

Conditions

Skin Inflammation

Outcome Measures

Primary Outcomes (2)

• Minimal erythema

  Standardized inflammation will be induced by irradiating test areas on the inner arm of subjects with defined doses of narrow band ultraviolet B (NB-UVB) light delivered by the Dermalight 90 handheld device (National Biological).

  16 weeks

• Skin Elasticity

  The Cutometer measures the vertical deformation of the skin in millimeters when the skin is pulled by means of a controlled vacuum into the circular aperture, 6mm in diameter, of the probe. In its standard configuration, the Cutometer is equipped with a measuring probe with a 2mm aperture because the device is originally designed to measure only the elastic properties of the epidermis. Skin hydration will measured using the moisture/hydration probe that attaches to the Cutometer. We will measure six sites: forehead, under the eye, frontal cheek, crow's foot, lateral cheek, and inner forearm.

  16 weeks

Secondary Outcomes (1)

• Skin Type Classification

  16 weeks

Study Arms (2)

Avocado

ACTIVE COMPARATOR

one avocado per day

Other: Avocado

Habitual Diet

PLACEBO COMPARATOR

maintain habitual diet

Other: Habitual diet

Interventions

Avocado OTHER

Subjects will eat one avocado in addition to their usual diet

Avocado

Habitual diet OTHER

Subjects will eat their usual diet

Habitual Diet

Eligibility Criteria

• Age: 25 Years - 90 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Female subjects
• Increased waist circumference defined as ≥35 inches for women (NCEP ATP III 2005)
• Women
• At least 25 years old at screening
• Not currently eating more than 2 avocados per month (habitual intake in U.S.)
• Non-smokers
• Fitzpatrick Skin type II-IV
• Willing to maintain their normal skin care pattern for the duration of the study (avoiding excessive sun, not beginning new skin treatments)
• Subjects must read and sign the Institutional Review Board-approved written informed consent prior to the initiation of any study specific procedures or enrollment

You may not qualify if:

• Does not eat avocados
• Sensitive / allergic to avocados
• Allergies to latex or oral allergy syndrome
• Not willing or unable to undergo MRI scans
• Unstable medical condition such as on dialysis for renal disease, cardiac, gastrointestinal, or hepatic disease, cancer (non-melanoma skin cancer \>5 years ago acceptable, any cancer site \>10yrs without recurrence).
• Pregnant, lactating, intention of pregnancy
• Lost or gained 10 lbs of body weight in last year
• Following restricted or weight loss dietary patterns
• Subjects who cannot avoid excessive exposure to either natural or artificial sunlight.
• Unstable anti-anxiety / anti-depressive / anti-psychotic medication use defined as dose change within last 6 months
• Currently taking any prescription medications that increase the risk of photosensitivity or history of taking such medications in the less than 3 months (e.g. alpha-hydroxy acids in cosmetics, antibiotics (ciprofloxacin, doxycycline, levofloxacin, ofloxacin, tetracycline, trimethoprim), antifungals (flucytosine, griseofulvin, voricanozole), antihistamines (cetirizine, diphenhydramine, loratadine, promethazine, cyproheptadine), Accutane
• Oral steroid use within the last 6 months longer than 7 days
• Elevated alcohol intake (7+ drinks/week females; 14+ drinks/week males)
• Participation in another clinical intervention trial within 30 days of baseline

Sponsors & Collaborators

• University of California, Los Angeles: lead
• Hass Avocado Board: collaborator

Study Sites (1)

UCLA Center for Human Nutrition

Los Angeles, California, 90024, United States

Location

MeSH Terms

Conditions

Dermatitis

Condition Hierarchy (Ancestors)

Skin Diseases; Skin and Connective Tissue Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Both groups will be instructed to continue to follow their habitual diet but the intervention group will receive one avocado per day
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants will be randomly assigned to one of two equally sized groups.

Study Record Dates

• First Submitted: August 24, 2021
• First Posted: November 1, 2021
• Study Start: January 1, 2020
• Primary Completion: December 30, 2020
• Study Completion: December 30, 2020
• Last Updated: November 1, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)