Effects of Avocado When Added to a Meat Patty on Inflammation in Healthy Men

NCT01397071 | Completed Results

• 1 other identifier: HAB-001
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

Avocados are naturally rich in antioxidants, or beneficial compounds, that can help prevent many diseases, like atherosclerosis (hardening of the arteries). When foods that are high in fats are eaten, certain harmful compounds can be absorbed, which can lead to atherosclerosis. One harmful compound is called malondialdehyde, or MDA. This compound can be measured in the blood and the urine after a person eats a high fat meal. Antioxidants found in herbs and spices may lower the absorption of MDA, which could help prevent the development of atherosclerosis. This study will determine whether the beneficial compounds of avocado can reduce absorption of MDA. This will be tested by asking healthy males to eat a high fat ground beef patty with or without avocado and then measuring the amount of MDA in their blood and urine samples. Blood flow will also be measured. Healthy men have been chosen for this study because eating high fat hamburger patties can easily mimic in them the condition that causes atherosclerosis. Avocados are rich in antioxidants, which have been shown in previous studies to reduce the absorption of harmful compounds, like MDA, that are formed during cooking. The results from this study may help to explain how high fat foods can be harmful to the body and how beneficial antioxidants from herbs and spices can protect the body. This will be determined from blood and urine samples after the subjects are given two different meals: a) a plain cooked ground beef patty, and b) or avocado with a cooked ground beef patty.

Conditions

Healthy Volunteers

Keywords

Avocado, antioxidant

Outcome Measures

Primary Outcomes (1)

• Change of Endothelial Function by Measurement of Flow-mediated Vasodilation Using the Reactive Hyperemia Index (RHI)

  Change from baseline in reactive hyperemia index (RHI) in response to consumption of 250 g beef patty with or without 68 g avocado added at 2 hour post-ingestion. RHI is a measure of endothelial dysfunction using noninvasive peripheral arterial tonometry (PAT). It is a ratio of the post-to-pre occlusion PAT amplitude of the tested arm, divided by the post-to-pre occlusion ratio of the control arm. RHI less than 1.67 is considered sign of endothelial dysfunction and RHI equal to or greater than 1.67 is considered normal function. The possible range of scores is 1 to 3. Increasing score indicates the improvement of coronary endothelial function.

  Baseline and 2 hours post-ingestion

Secondary Outcomes (1)

• Change in Inflammation Marker Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-cells Inhibitor Alpha (IkB-alpha)

  0 (baseline) and 3 hours post-ingestion

Study Arms (2)

Ground Beef Patty with Avocado

ACTIVE COMPARATOR

Test burgers with fresh avocado added just prior to consumption

Other: Avocado

Ground Beef Patty without Avocado

ACTIVE COMPARATOR

Test burgers

Other: Avocado

Interventions

Avocado OTHER

Fresh Avocado

Ground Beef Patty with Avocado; Ground Beef Patty without Avocado

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years old males (inclusive)
• Non-smokers
• Must weigh a minimum of 110 pounds
• Willing to maintain normal activity and eating patterns for the duration of the study
• Willing to maintain their normal diet for the duration of the study but avoid dairy, avocado and meat products.

You may not qualify if:

• Females
• Abnormal liver function (aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \> 2 x upper limit)
• Currently taking steroidal drugs
• Known HIV positive or AIDS
• Chronic infectious disease
• Cancer treated within the past two years
• Participation in a therapeutic research study within 30 days of baseline
• Consumption of vegetarian diet
• Allergy or sensitivity to dairy products
• Allergic to avocado

Sponsors & Collaborators

• University of California, Los Angeles: lead

Study Sites (1)

UCLA Center for Human Nutriiton

Los Angeles, California, 90095, United States

Location

Related Publications (1)

• Li Z, Wong A, Henning SM, Zhang Y, Jones A, Zerlin A, Thames G, Bowerman S, Tseng CH, Heber D. Hass avocado modulates postprandial vascular reactivity and postprandial inflammatory responses to a hamburger meal in healthy volunteers. Food Funct. 2013 Feb 26;4(3):384-91. doi: 10.1039/c2fo30226h.

  PMID: 23196671 RESULT

Results Point of Contact

• Title: Zhaoping Li
• Organization: UCLA Department of Medicine/Center for Human Nutrition

zli@mednet.ucla.edu

310-206-1987

Study Officials

• David Heber, MD, PhD

  UCLA Center for Human Nutrition

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine

Study Record Dates

• First Submitted: July 18, 2011
• First Posted: July 19, 2011
• Study Start: August 1, 2011
• Primary Completion: February 1, 2012
• Study Completion: August 1, 2012
• Last Updated: September 25, 2019
• Results First Posted: September 25, 2019

Record last verified: 2019-09

Locations

US (1)