Anorexia Nervosa and Its Effects on Brain Function, Body Metabolism and Their Interaction

NCT05101538 | Completed

• 1 other identifier: T113/2020
• Study Type: observational
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

The neuromolecular and metabolic underpinnings of Anorexia Nervosa (AN) are studied using multi-modal molecular (positron emission tomography with two different radioligands) and functional (functional magnetic resonance imaging) neuroimaging in a prospective design. Subjects with AN and normal weight adolescents will be studied with PET and MRI and followed for five years.

Conditions

Anorexia Nervosa

Keywords

Anorexia nervosa; metabolism; functional imaging; PET

Outcome Measures

Primary Outcomes (2)

• Changes in brain reward system and metabolism in AN patients

  AN patients and controls are studied using fMRI and PET imaging and followed 10 years. Reward system function is measured using functional MRI and metabolism using 18F-fluorodeoxy glucose and PETCT imaging

  10 years

• Predictive value of baseline body mass index (BMI), functional brain activation and metabolism in AN

  Results from baseline are combined with follow updata

  10 y

Study Arms (1)

patients and controls

AN patients and controls are recruited, studied using imaging and followed for 5 years

Eligibility Criteria

• Age: 18 Years - 32 Years
• Gender Eligibility Details: AN is more frequent in females, rare in males.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Totallly 30 female subjects with anorexia nervosa are recuited from the Eating Disorder Unit at the Turku University Hospital who meet the following criteria: i) modified DSM-IV diagnosis of AN with or without amenorrhea; ii) AN onset before the age of 25 years; iii) age between 18 and 32 3 years; iv) no lifetime history of binge eating. Their data are compared with 30 age and sex-matched healthy controls

You may qualify if:

• Female sex
• Age 18-32 3 years
• BMI \< 17.5 kg/m2
• Currently fulfilling modified DSM-IV diagnosis of AN with or without amenorrhea, onset age before 25 years
• Diagnosed less than 2 years ago
• For controls:
• Female sex
• Age 18-32 3 years
• BMI 19 20-25 kg/m2
• No lifetime history of obesity (BMI ≥\> 30) or eating disorders

You may not qualify if:

• Any chronic disease or medication that could affect glucose metabolism or neurotransmission
• History of psychiatric disorders (excl. AN for the corresponding study group)
• Smoking of tobacco, taking of snuffs, or use of narcotics
• Abusive use of alcohol

Sponsors & Collaborators

• Turku University Hospital: lead

Study Sites (1)

Turku PET Centre

Turku, 20521, Finland

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood sample

MeSH Terms

Conditions

Anorexia Nervosa

Condition Hierarchy (Ancestors)

Feeding and Eating Disorders; Mental Disorders

Study Officials

• Pirjo Nuutila, MD, PhD

  Turku PET Centre, Turku University hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 12, 2021
• First Posted: November 1, 2021
• Study Start: November 1, 2020
• Primary Completion: November 1, 2024
• Study Completion: November 1, 2024
• Last Updated: December 17, 2024

Record last verified: 2024-12

Locations

FI (1)