Loiasis Cross-reactive Antigenemia and Treatment-related Adverse Events
1 other identifier
interventional
41
1 country
1
Brief Summary
This study seeks to determine which Loa loa antigens are released into circulation when infected individuals are treated with ivermectin.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_4
Started Jul 2021
Shorter than P25 for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 30, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2021
CompletedFirst Submitted
Initial submission to the registry
October 7, 2021
CompletedFirst Posted
Study publicly available on registry
October 20, 2021
CompletedResults Posted
Study results publicly available
September 29, 2022
CompletedSeptember 29, 2022
August 1, 2022
1 month
October 7, 2021
August 30, 2022
August 30, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Cross-reactive Antigenemia
N of participants with detectable Loa loa antigens in sera that cross-react with diagnostic tests for lymphatic filariasis (Filariasis Test Strip) on either day 1, 2, 3, or 7 post-treatment
7 days
Study Arms (1)
Ivermectin
EXPERIMENTALAll eligible participants received a single dose (150 ug/kg) ivermectin by mouth
Interventions
Eligibility Criteria
You may qualify if:
- Loa loa blood microfilariae of between 5,000 - 18,000 per mL
You may not qualify if:
- known allergy to ivermectin; severe comorbidities
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Centre de Recherche sur les Filarioses et autres Maladies Tropicales (CRFilMT)
Yaoundé, Cameroon
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Philip Budge
- Organization
- Washington University in St. Louis
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 7, 2021
First Posted
October 20, 2021
Study Start
July 30, 2021
Primary Completion
August 31, 2021
Study Completion
September 30, 2021
Last Updated
September 29, 2022
Results First Posted
September 29, 2022
Record last verified: 2022-08