Diet and Hip Fracture Risk in the United Kingdom Women's Cohort
Associations Between Diet and Hip Fracture Incidence in the United Kingdom Women's Cohort
1 other identifier
observational
35,372
1 country
1
Brief Summary
Hip fracture is a common serious injury in older women that reduces quality of life and can lead to premature death. In the United Kingdom, hip fractures are estimated to account for 1.5 million hospital bed days used per year due to long hospitalisation and rehabilitation periods post-surgery, costing the National Health Service over £1 billion per year. Diet can affect bone health and risk of hip fracture, with varying risks in women on specific diets, and specific foods and nutrients playing more important roles than others. Vegetarians may be at a greater risk of hip fracture than meat-eaters, and those who don't consume enough protein could be at a greater risk than those with adequate intakes. This research aims to investigate which dietary factors (and in what quantities) might predispose United Kingdom women to a greater risk of hip fracture, and which factors may be protective. The purpose of this study is to better understand the role of diet in reducing hip fracture risk in United Kingdom women. The research will use existing dietary and lifestyle data from the United Kingdom Women's Cohort Study and hospital records of hip fractures.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 1995
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 15, 1995
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 13, 2019
CompletedFirst Submitted
Initial submission to the registry
October 5, 2021
CompletedFirst Posted
Study publicly available on registry
October 18, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
July 31, 2022
CompletedSeptember 23, 2022
September 1, 2022
24.2 years
October 5, 2021
September 21, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Hip fracture incidence (first)
Incidence of first hip fracture ascertained from linkage to Hospital Episode Statistics (HES) data
age when the completed questionnaire was returned (1995-1998) until age at event, death, or end of study period (19 Mar 2019)
Study Arms (1)
United Kingdom Women's Cohort
United Kingdom Women's Cohort Study. No interventions are to be administered in this observational prospective cohort study.
Interventions
(regular meat-eater, occasional meat-eater, fish-eater, vegetarian, and vegan)
Intake of fruits, vegetables, fruits and vegetables combined from food frequency questionnaire
Red meat, poultry, processed meat from food frequency questionnaire
Intake of dairy products from food frequency questionnaire
Intake of coffee (caffeinated or decaffeinated) from food frequency questionnaire
Combined intake of tea and coffee from food frequency questionnaire
Estimated intake of protein, derived from food frequency questionnaire
Estimated intake of calcium, derived from food frequency questionnaire
Estimated intake of vitamin D, derived from food frequency questionnaire and any recorded supplemental intake
Eligibility Criteria
The UK Women's cohort profile is published here: \[https://doi.org/10.1093/ije/dyv173\].
You may qualify if:
- Female
- Ages 35 - 69 years at time of recruitment
- Able to provide informed consent
You may not qualify if:
- Male
- Not a resident of England
- Unable to link dietary and lifestyle data with hospital episode data
- Missing covariate data
- Hip fracture or osteoporosis prevalence before or on the date of recruitment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Leeds
Leeds, West Yorkshire, LS2 9JT, United Kingdom
Related Publications (2)
Webster J, Greenwood DC, Cade JE. Risk of hip fracture in meat-eaters, pescatarians, and vegetarians: results from the UK Women's Cohort Study. BMC Med. 2022 Aug 11;20(1):275. doi: 10.1186/s12916-022-02468-0.
PMID: 35948956RESULTWebster J, Greenwood DC, Cade JE. Foods, nutrients and hip fracture risk: A prospective study of middle-aged women. Clin Nutr. 2022 Dec;41(12):2825-2832. doi: 10.1016/j.clnu.2022.11.008. Epub 2022 Nov 9.
PMID: 36402009DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Senior Lecturer in Biostatistics
Study Record Dates
First Submitted
October 5, 2021
First Posted
October 18, 2021
Study Start
January 15, 1995
Primary Completion
March 13, 2019
Study Completion
July 31, 2022
Last Updated
September 23, 2022
Record last verified: 2022-09
Data Sharing
- IPD Sharing
- Will not share