Effect of Extubation on Respiratory Function

NCT05077605 | Completed

• 2 other identifiers: 2020-CHITS-0012021-A00785-36
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The extubation phase is a risky period of anesthesia management. During this step, serious complications can arise: hypoxemia, laryngospasm, pharyngeal obstruction, pneumonia… In spite of these complications, extubation and its impact on respiratory function, particularly on the Functional Residual Capacity (FRC), remains poorly studied because of the difficulty to make bedside measurements. The PulmoVista 500 is a clinical routine which provide effective non-invasive bedside measurements. It would be interesting to evaluate the impact of extubation on respiratory function, and more specifically FRC changes during and after extubation. This study will allow a better physiopathological knowledge and a quality improvement patient extubation management.

Conditions

Functional Residual Capacity

Keywords

Extubation; Functional residual capacity; Electrical impedance tomography; Pulmovista; Respiratory function

Outcome Measures

Primary Outcomes (1)

• End Expiratory Lung Impedance (EELI)

  EELI variation before and at different timepoints after extubation: T0, T5, T10, T15 and T20 (min).

  Between 2 and 3 hours

Secondary Outcomes (4)

• Tidal volume distribution

  Between 2 and 3 hours

• Tidal volume distribution depending on patient position

  Between 2 and 3 hours

• Tidal volume distribution depending on surgery type and duration

  Between 2 and 3 hours

• Tidal volume distribution depending on ventilatory mode

  Between 2 and 3 hours

Study Arms (1)

Functional residual capacity

EXPERIMENTAL

Functional residual capacity measure during and after extubation

Other: Functional residual capacity measure by electrical impedance tomography

Interventions

Functional residual capacity measure by electrical impedance tomography OTHER

Patient functional residual capacity will be measured by electrical impedance tomography before extubation and then at 0, 10, 15 and 20 min after extubation.

Functional residual capacity

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient over 18 years
• Patient in operating room for scheduled surgery
• Patient receiving general anaesthesia with orotracheal intubation
• Patient given written consent after information
• Patient covered by social security or equivalent regimen

You may not qualify if:

• Patient undergoing thoracic and spinal surgery, due to the presence of dressings that interfere with measurements,
• Patient who has undergone intracerebral surgery because of possible communication difficulties upon awakening,
• Patients with a body mass index (BMI) \> 50 (measurements not possible)
• Pregnant or breastfeeding patient,
• Patient contraindicated to the use of a thoracic electroimpedancemetry technique: dressings, wounds, presence of a pacemaker, defibrillator or any other active implant.
• Patient deprived of liberty by a judicial or administrative decision or patient subject to a legal protection measure (guardianship, curatorship...)
• Any other reason that, in the opinion of the investigator, could interfere with the evaluation of study objectives

Sponsors & Collaborators

• Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer: lead

Study Sites (1)

Hôpital d'Instruction des Armées de Sainte Anne

Toulon, Var, 83100, France

Location

MeSH Terms

Conditions

Respiratory Aspiration

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Clarisse LEGER, Nurse

  Hôpital d'instruction des armées Sainte-Anne

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 1, 2021
• First Posted: October 14, 2021
• Study Start: November 5, 2021
• Primary Completion: June 30, 2022
• Study Completion: June 30, 2022
• Last Updated: April 13, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)