Functional Residual Capacity (FRC) Guided Alveolar Recruitment Strategy
The Influence of a Functional Residual Capacity Guided Alveolar Recruitment Strategy After Open Endotracheal Suctioning on Oxygenation and Regional Ventilation
1 other identifier
interventional
59
0 countries
N/A
Brief Summary
In ventilated patients open endotracheal suctioning may lead to alveolar derecruitment, which can be monitored by means of functional residual capacity (FRC) measurements. The investigators hypothesized that a recruitment strategy based on FRC measurements would improve oxygenation and regional ventilation after an open endotracheal suctioning manoeuvre.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_4
Started Oct 2007
Shorter than P25 for phase_4
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2008
CompletedFirst Submitted
Initial submission to the registry
October 22, 2008
CompletedFirst Posted
Study publicly available on registry
October 24, 2008
CompletedOctober 24, 2008
October 1, 2008
6 months
October 22, 2008
October 22, 2008
Conditions
Outcome Measures
Primary Outcomes (1)
Arterial oxygenation
60 minutes
Secondary Outcomes (1)
Regional ventilation
60 minutes
Study Arms (4)
Group A_RM
EXPERIMENTALPatients with FRC after open endotracheal suctioning of more than 94% of baseline randomized to receive an alveolar recruitment manoeuvre.
Group A_NRM
NO INTERVENTIONPatients with FRC after open endotracheal suctioning of more than 94% of baseline randomized to receive no alveolar recruitment manoeuvre.
Group B_RM
EXPERIMENTALPatients with FRC after open endotracheal suctioning of less than 94% of baseline randomized to receive an alveolar recruitment manoeuvre.
Group B_NRM
NO INTERVENTIONPatients with FRC after open endotracheal suctioning of less than 94% of baseline randomized to receive no alveolar recruitment manoeuvre.
Interventions
Increase airway pressure during pressure controlled ventilation up to peak-airway pressure of 40 cmH20 and PEEP of 15 cmH20.
Eligibility Criteria
You may qualify if:
- ventilated after elective cardiac surgery
You may not qualify if:
- hemodynamic instability (eg. intraaortic balloon pump)
- acute lung injury, i.e. PEEP \> 10cmH20 or FiO2 \> 0.4
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Heinze H, Eichler W, Karsten J, Sedemund-Adib B, Heringlake M, Meier T. Functional residual capacity-guided alveolar recruitment strategy after endotracheal suctioning in cardiac surgery patients. Crit Care Med. 2011 May;39(5):1042-9. doi: 10.1097/CCM.0b013e31820eb736.
PMID: 21336125DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Hermann Heinze, MD
Department of Anaesthesiology, University of Lübeck
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
October 22, 2008
First Posted
October 24, 2008
Study Start
October 1, 2007
Primary Completion
April 1, 2008
Study Completion
October 1, 2008
Last Updated
October 24, 2008
Record last verified: 2008-10