Suicide Attempts and Tramadol : a Case Report

NCT05075291 | Completed

• 1 other identifier: RECHMPL21_0571
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

In France, over the last years the use weak opioid analgesics decreased́, whereas that of strong opioid analgesics (OFMA). Hospitalizations for opioid overdose increased́ by 128% from 2000 to 2015, and deaths related to prescribed opioid overdose increased significantly, by 161%, from 2000 to 2014.In addition, recent studies suggest a link between opioid system dysfunction and suicidal behavior. In parallel, studies are emerging showing the potential interest of using Tramadol as an antidepressant. Indeed, this opiate analgesic also acts on the serotonergic and dopaminergic systems, and would have an antidepressant effect.Thus, the investigators can legitimately wonder whether the use of Tramadol as an antidepressant might not pose a problem in patients at risk of suicide. This study aims to describe a clinical case of a patient hospitalized in the Department of Psychiatric Emergency and Post-Emergency (Montpellier University Hospital) who developed a severe addiction to Tramadol (consumption up to 5 times the maximum recommended dose per day) and evaluate whether this may have increased her suicidal risk, in order to warn prescribers about the suicidal risk of Tramadol.

Conditions

Suicide, Attempted; Addiction

Keywords

Suicide; Addiction; Opioids

Outcome Measures

Primary Outcomes (1)

• Lifetime suicidal events

  Occurrence of suicidal events (actuel, interrupted and aborted or self-aborted suicide attempts) based on the patient medical records.

  day 1

Secondary Outcomes (4)

• Depressive symptomatology

  day 1

• Suicidal ideation

  day 1

• Psychological pain

  day 1

• Anxiety

  day 1

Eligibility Criteria

• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A single patient with multiple suicide attempts related to her addiction to Tramadol.

You may qualify if:

• Multiple suicide attempts
• Tramadol addiction
• NA : patient case report

You may not qualify if:

• \- None

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

Uhmontpellier

Montpellier, 34295, France

Location

MeSH Terms

Conditions

Suicide, Attempted; Behavior, Addictive; Suicide

Condition Hierarchy (Ancestors)

Self-Injurious Behavior; Behavioral Symptoms; Behavior; Compulsive Behavior; Impulsive Behavior

Study Officials

• Bénédicte NOBILE, PharmD, PhD

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 18, 2021
• First Posted: October 12, 2021
• Study Start: November 1, 2020
• Primary Completion: November 1, 2020
• Study Completion: July 30, 2021
• Last Updated: October 12, 2021

Record last verified: 2021-09

Locations

FR (1)