The Life Paths That Lead Teenagers to Attempted Suicide:Trajectories of Proximal Adversity

NCT04638205 | Completed

• 2 other identifiers: 2018_202018-A03065-50
• Study Type: observational
• Target: 39
• Locations: 1 country
• Sites: 1

Brief Summary

Suicidal behaviors seriously alter the vital and functional prognosis of adolescents. Although the literature has lighted out a considerable number of risk factors for suicide attempts in youth, theoretical models - among which bio-psycho-social models - still lack empirical evidence. More specifically, the way adverse life events dynamically interact together and with the individual's diathesis to precipitate suicidal attempts remains unclear. Studies of life trajectories have opened an alternative approach to traditional linear epidemiological analysis to capture such a complex process. To date, adverse trajectories approaches never have been applied to the period immediately preceding the occurrence of the suicidal gesture (proximal adverse trajectories).

Conditions

Suicide, Attempted

Keywords

Suicide attempt; adolescence; adverse life event; developmental model; trajectories

Outcome Measures

Primary Outcomes (1)

• Growth parameters of the patterns of proximal adverse trajectories in adolescents who attempted suicide, as compared to non-suicidal adolescents

  We will build growth mixture models to account for the 1-year longitudinal evolution of the Burden of Adversity values. Each group will be characterized by the parameters (intercepts and slopes) of the best-fitting model. We will the compare the parameters of the 2 groups to search for statistical differences

  1 year

Secondary Outcomes (3)

• Statistical tests comparing the sociodemographic, vulnerabily and psychopathological indicators between the sub-group of adolescents identified from the mixture model.

  1 year

• Growth parameters of the patterns of evolution of psychological pain

  1 year

• Growth parameters of the patterns of evolution of suicidal ideation intensity

  1 year

Study Arms (2)

Suicide attempt cases

Adolescents and young adults who attempted suicide between 7 and 30 days prior the inclusion

Non-suicidal controls

Adolescents and young adults without history of suicide attempt or ideation

Eligibility Criteria

• Age: 15 Years - 24 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Patient recruitment will be supported by the VigilanS program. VigilanS is a suicide recurrence prevention device implemented in all establishments in the Hauts-de-France region that receive patients who have attempted suicide (www.dispositifvigilans.org).

You may qualify if:

• Youth aged 15-24 inclusive
• Who stayed at the hospital or in the emergency room for less than 15 days after a first suicide attempt
• Who were discharged less than 15 days ago
• Youth aged 15-24 inclusive
• Who have never experienced any suicidal ideation or suicide attempt
• Close relatives of the participant
• Who are major
• Who lived in the same household as the participant or have interacted with him/her for more than half the weeks of the year preceding the index suicide attempt

You may not qualify if:

• No consent or consent withdrawal for majors and/or their parents for minors
• Neurological or psychiatric condition altering the capacity to understand

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

Hop Fontan - Chu Lille

Lille, 59037, France

Location

MeSH Terms

Conditions

Suicide, Attempted

Condition Hierarchy (Ancestors)

Suicide; Self-Injurious Behavior; Behavioral Symptoms; Behavior

Study Officials

• Charles-Edouard Notredame, MD

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 9, 2020
• First Posted: November 20, 2020
• Study Start: November 1, 2019
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: December 26, 2025

Record last verified: 2025-12

Locations

FR (1)