Isothiocyanates and Metabolic Health

NCT05070585 | Unknown Phase 1

• 1 other identifier: SwedishSchoolSport
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Many sprouts, for example broccoli sprouts, contain substances that have shown to have protective effects, both against oxidative stress and against carcinogenic substances. In this study we will investigate the activation of the body's antioxidant defense system and effect on blood lactate and glucose after 1 week of isothiocyanate rich sprout supplementation. The subjects will perform maximal and submaximal work test, blood sampling, muscle biopsies and blood pressure monitoring post supplementation. We hypothesize that 1 week of supplementation of isothiocyanate rich sprouts alters blood lactate and glucose metabolism and activates the body's antioxidant defense system.

Conditions

Metabolic Disturbance

Keywords

Isothiocyanates; Blood lactate; Glucose regulation; Nrf2

Outcome Measures

Primary Outcomes (3)

• Blood lactate

  Changes in blood lactate during exercise

  Acute during sub maximal exercise

• Nrf2 activation

  Increased Nrf2 protein in human skeletal muscle

  Acute after 1 week of supplementation

• Glucose regulation

  Improved continuous glucose control

  Throughout 1 week of supplementation

Secondary Outcomes (2)

• Glucose tolerance test

  120 minutes

• Clinic blood pressure

  Acute after 1 week of supplementation

Study Arms (2)

Isothiocyanate Rich Juice

EXPERIMENTAL

The juices will contain 37,5g isothiocyanate rich sprouts and be delivered frozen to the subjects. The subjects will be instructed to consume two juices per day.

Dietary Supplement: Isothiocyanate rich sprouts

Placebo Juice

PLACEBO COMPARATOR

The juices will contain 37,5g alfalfa sprouts and be delivered frozen to the subjects. The subjects will be instructed to consume two juices per day.

Dietary Supplement: Placebo Juice

Interventions

Isothiocyanate rich sprouts DIETARY_SUPPLEMENT

Isothiocyanate rich sprout juice consumption for 1 week

Isothiocyanate Rich Juice

Placebo Juice DIETARY_SUPPLEMENT

Sprout juice devoid of isothiocyanates for 1 week

Placebo Juice

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy volunteer
• years old

You may not qualify if:

• Any chronic disease
• Inability to perform cycling exercise
• Allergic to anesthesia

Sponsors & Collaborators

• The Swedish School of Sport and Health Sciences: lead

Study Sites (1)

Swedish School of Sports and Health Sciences

Stockholm, 114 86, Sweden

Location

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: The subjects will receive a sprout juice or a placebo juice made of alfalfa sprouts.
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomized, placebo controlled, cross-over study

Study Record Dates

• First Submitted: September 1, 2021
• First Posted: October 7, 2021
• Study Start: October 20, 2021
• Primary Completion: December 1, 2022
• Study Completion: December 5, 2023
• Last Updated: December 6, 2022

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)