CARBON: UAB Cardiovascular Research Biobank

NCT05067231 | Recruiting DMC

• 1 other identifier: IRB - 300007834
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The UAB Cardiovascular Research Biobank (CARBON) will be a resource that contains biological materials, such as DNA samples, in addition to health and personal information on a large number of people over time. It will be set up so that it can be used in the future as a resource for researchers undertaking a wide range of medical research.

Conditions

Natriuretic Peptides; Cardiovascular Diseases; Hypertension; Diabetes; Obesity

Keywords

Natriuretic Peptides; Cardiovascular Diseases; Hypertension; Diabetes; Obesity

Outcome Measures

Primary Outcomes (1)

• Genetic Variants in the NPPA and NPPB gene of the Natriuretic Peptide family associated with the Cardiovascular and Metabolic Diseases

  Baseline

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals living in the Birmingham area will be enrolled through the University of Alabama at Birmingham campus. We will also enroll individuals who are associated with the University of Alabama at Birmingham.

You may qualify if:

• Age more than or equal to 18

You may not qualify if:

• Age \<18, at screening
• Employees or students associated with the Division of Cardiovascular Disease at UAB will not be recruited due to their vulnerable status and susceptibility to coercion.
• Women who are pregnant or who can become pregnant and not practicing an acceptable method of birth control.

Sponsors & Collaborators

• University of Alabama at Birmingham: lead

Study Sites (1)

University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

RECRUITING

Related Publications (1)

• Bajaj NS, Gutierrez OM, Arora G, Judd SE, Patel N, Bennett A, Prabhu SD, Howard G, Howard VJ, Cushman M, Arora P. Racial Differences in Plasma Levels of N-Terminal Pro-B-Type Natriuretic Peptide and Outcomes: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. JAMA Cardiol. 2018 Jan 1;3(1):11-17. doi: 10.1001/jamacardio.2017.4207.

  PMID: 29167879 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

DNA, RNA, Plasma and Serum to be collected

MeSH Terms

Conditions

Cardiovascular Diseases; Hypertension; Diabetes Mellitus; Obesity

Condition Hierarchy (Ancestors)

Vascular Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Pankaj Arora, MD, FAHA

  University of Alabama at Birmingham

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nehal Vekariya, MS

CONTACT

205-934-7173; nvekariya@uabmc.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor, Division of Cardiovascular Disease, Department of Medicine

Study Record Dates

• First Submitted: September 23, 2021
• First Posted: October 5, 2021
• Study Start: January 1, 2022
• Primary Completion (Estimated): January 1, 2030
• Study Completion (Estimated): January 1, 2030
• Last Updated: February 13, 2026

Record last verified: 2026-02

Locations

US (1)