Normative Cardiovascular Magnetic Resonance Values for Measurement of Cardiovascular Structure and Function at MCMR
NORMAL MCMR
3 other identifiers
observational
122
1 country
1
Brief Summary
Cardiovascular magnetic resonance (CMR) imaging is an important clinical and research tool. Measurements of cardiovascular structure and function can vary according to scanner vendor, scanner field strength, imaging sequence and patient population. As such, the Society for Cardiovascular Magnetic Resonance (SCMR) and the European Association for Cardiovascular Imaging (EACVI) state that local normal reference ranges for CMR measurements should be established. This study plans to establish reference ranges for measurements of cardiovascular structure and function at the British Heart Foundation Manchester Centre for Heart and Lung Magnetic Resonance Research (MCMR). The work will underpin many other research projects and clinical practice. The study will involve volunteers having a CMR scan that will last around 30 minutes. No contrast agent will be administered. MRI scanning uses magnetic fields to make the pictures. The NHS website describes MRI scanning as "a painless and safe procedure" and "one of the safest medical procedures available".
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Oct 2021
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 23, 2021
CompletedFirst Posted
Study publicly available on registry
October 4, 2021
CompletedStudy Start
First participant enrolled
October 5, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 4, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2022
CompletedMarch 30, 2023
March 1, 2023
12 months
September 23, 2021
March 29, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Normative Cardiac MRI values
Development of normative cardiac MRI values for MCMR unit.
1 year
Eligibility Criteria
120 healthy volunteers. separated into 12 equal sized groups. Groups will be separated by age and gender.
You may qualify if:
- Written, informed consent.
- Aged 18 and over
- No known history of cardiovascular disease. It is recognised that it may be difficult to recruit older participants entirely free from cardiovascular disease, thus participants with relatively milder cardiovascular disease may be permitted, at the discretion of the investigator.
You may not qualify if:
- Contraindication to MRI scanning, such as pacemaker, defibrillator, intraocular metal, prohibitive intracranial aneurysm clips or severe claustrophobia.
- Unable to provide complete written or verbal consent in English.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Manchester University NHS Foundation Trust
Manchester, Greater Manchester, M23 9LT, United Kingdom
Study Officials
- PRINCIPAL INVESTIGATOR
Chris Miller
University of Manchester
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 1 Month
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 23, 2021
First Posted
October 4, 2021
Study Start
October 5, 2021
Primary Completion
October 4, 2022
Study Completion
December 31, 2022
Last Updated
March 30, 2023
Record last verified: 2023-03
Data Sharing
- IPD Sharing
- Will not share
With participant consent, the pseudo-anonymised MRI scans and relevant data (such as age, sex, body surface area), may be shared with researchers in other hospitals and academic institutions. The code linking the participant number to the participant will be held at Manchester University NHS Foundation Trust and will not be shared.