Parkinson Progression Marker Initiative Online (PPMI Online)
Parkinson's Progression Markers Initiative Online Study (PPMI Online)
1 other identifier
observational
500,000
1 country
1
Brief Summary
Parkinson Progression Marker Initiative Online (PPMI Online) is an observational study collecting participant reported information from people with and without Parkinson's disease (PD), for the goal of better understanding risk and predictive factors for PD. PPMI Online is part of the broader Parkinson Progression Marker Initiative aimed at identifying markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2021
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 28, 2021
CompletedFirst Submitted
Initial submission to the registry
September 2, 2021
CompletedFirst Posted
Study publicly available on registry
October 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2041
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2041
November 25, 2024
November 1, 2024
20.4 years
September 2, 2021
November 21, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Unified Parkinson's Disease Rating Scale Ib & II
Evaluates self-reported motor and nonmotor Parkinson's disease symptoms
Baseline to 240 months
Interventions
Observation
Eligibility Criteria
In PPMI Online, up to 500,000 participants with and without PD will be enrolled and contribute data longitudinally and cross-sectionally using a web-based platform.
You may qualify if:
- Parkinson Disease (PD) Participants:
- Male or female age 18 years or older.
- Has received a diagnosis of Parkinson's disease
- Participants without PD:
- Male or female age 18 years or older.
- Has not received a diagnosis of Parkinson's disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
UCSF Movement Disorders and Neuromodulation Center (MDNC)
San Francisco, California, 94143, United States
Related Publications (1)
Pierz KA, Aamodt W, Gochanour C, Kurth R, Brumm MC, Coffey CS, Heathers LE, Totten M, Doty RL, Marek K, Siderowf A; Parkinson's Progression Markers Initiative. Percentile scores for the revised University of Pennsylvania Smell Identification Test for 16,972 individuals 60 years of age and older. NPJ Parkinsons Dis. 2025 Oct 1;11(1):280. doi: 10.1038/s41531-025-01095-9.
PMID: 41034300DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Caroline Tanner, MD, PhD
University of California, San Francisco
- PRINCIPAL INVESTIGATOR
Kenneth L Marek, MD
Institute for Neurodegenerative Disorders
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Protocol Co- Principal Investigator
Study Record Dates
First Submitted
September 2, 2021
First Posted
October 1, 2021
Study Start
July 28, 2021
Primary Completion (Estimated)
December 1, 2041
Study Completion (Estimated)
December 1, 2041
Last Updated
November 25, 2024
Record last verified: 2024-11