Incontinence and MRI Results in Children with Cerebral Palsy

NCT05060211 | Completed

• 1 other identifier: B6702021000735
• Study Type: observational
• Target: 125
• Locations: 1 country
• Sites: 1

Brief Summary

More than 50 % of children and adults with cerebral palsy experience lower urinary tract symptoms (LUTS). This can negatively influence quality of life of the child and the total social environment. Previous research demonstrated that the brain lesion, characteristic for cerebral palsy (CP), is a prognostic factor for the functional abilities of a child with CP. Previous research within our department demonstrated functional impairment as a risk factor for incontinence. This demonstrates an indirect connection between the brain lesion and incontinence of a child with CP. However, this connection isn't alway correct as some children with high functionality also demonstrate incontinence. As bladder control is also regulated by higher brain centers, the present study wants to investigate a direct connection between the brain lesion of the child, visible by means of MRI, and the incontinence status of the child. .

Conditions

Cerebral Palsy; Lower Urinary Tract Symptoms

Keywords

cerebral palsy; lower urinary tract symptoms; Magnetic resonance imaging; brain lesion; incontinence

Outcome Measures

Primary Outcomes (1)

• Incontinence ratio

  Amount of patients with incontinence in the different MRICS-groups (MRI classification system for children with CP).

  During cross-sectional testing

Secondary Outcomes (2)

• Amount of Lower urinary tract symptoms in different MRICS-groups

  During cross-sectional testing

• Amount of bladder symptoms in different MRICS-groups

  During cross-sectional testing

Interventions

Vancouver symptom score for dysfunctional elimination syndroms OTHER

Validated questionnaire concerning bladder and bowel symptoms

Also known as: VSSDES

Magnetic resonance imaging OTHER

Known MRI results of the patient file

Also known as: MRI

Eligibility Criteria

• Age: 5 Years - 12 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Children with cerebral palsy attending yearly or half yearly follow-up consultation

You may qualify if:

• Diagnosis of cerebral palsy
• MRI investigation in history
• Dutch or French speaking child and parent

You may not qualify if:

• No MRI investigation in history
• Child or parent not speaking Dutch or French

Sponsors & Collaborators

• University Hospital, Ghent: lead
• University Ghent: collaborator

Study Sites (1)

Ghent University Hospital

Ghent, Flanders, 9000, Belgium

Location

MeSH Terms

Conditions

Cerebral Palsy; Lower Urinary Tract Symptoms

Interventions

Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Brain Damage, Chronic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques

Study Officials

• Bieke Samijn, dr.

  Ghent University Hospital/Ghent University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 16, 2021
• First Posted: September 29, 2021
• Study Start: October 25, 2021
• Primary Completion: June 30, 2023
• Study Completion: June 30, 2023
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)