Comparison Among the Effects of Blood Flow Restriction Training and Conventional Exercise in Knee Osteoarthritis.

NCT05058794 | Completed DMC

• 1 other identifier: REC/00947 Farah Anwar
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 2

Brief Summary

The main objective of the study is to compare the effects of Blood flow Restriction training vs. traditional exercises on knee pain , knee functional disability and on quadriceps strength in patient with knee osteoarthritis.

Conditions

Osteoarthritis, Knee; Hypertrophy

Keywords

Osteoarthritis; Blood Flow Restriction; Quadriceps; Resistance Training

Outcome Measures

Primary Outcomes (4)

• Muscle strength

  Measurement of Quadriceps strength with portable weight machine.

  6 weeks

• Thigh Girth

  Participants will be supine lying and knee in extension, standing or knee at 90 degree. Proximal to the patellar pole superiorly one measurement with a non-elastic tape at the inguinal fold, then mark the mid-point at the mid-thigh level measuring in centimeters/inches.

  6 weeks

• Numeric Pain Rating Scale ( NPRS)

  Patient will be asked if there is any pain in knee from the scale of 0 to 10.

  6 weeks

• Q angle Measurement

  Subject will be in supine position with knee extension and quadriceps are relaxed, examiner will measure the q angle with flexible inch tape and goniometer. The Q- angle is measured by extending a line through the center of the patella to the anterior superior iliac spine and another line from the tibial tubercle through the center of the patella.

  6 weeks

Study Arms (2)

Resistance exercise group

EXPERIMENTAL

During each exercise, only blood flow in the involved leg was restricted using an aneroid sphygmomanometer. Prior to exercise the cuff was placed on the most proximal portion of the limb and LOP was calculated in the body position that the blood flow restriction (BFR) stimulus would be applied. BFR pressure was set at 50% occlusion.Resistance applied for 1 minute (60 sec) with 30 % load of 1 repetition maximum. Subjects will receive treatment bilaterally.Participants will perform exercises 2 sets with 15 repetitions through 0 to 90 degrees. Secondly, Rest between sets (1 min) Therapist will help these positions to maintain Knee extension and Wall Squatting. The study includes interventional protocol of 6 weeks. Total sessions will be 12 and in each week there will 2 sessions with alternative days and follow up.

Other: Blood flow Restriction/Resistance Training

Conventional Therapy Group

ACTIVE COMPARATOR

Patients in this group will receive treatment via Knee extension,Wall squatting Each training session includes 3 minutes warm-up.First, participants will perform 2 sets with 15 repetitions in (0 to 90 degree.) Secondly, Rest between sets (1 min) Resistance applied for 1 minute (60 sec) with 30 % load of 1 repetition maximum. Subjects will receive treatment bilaterally. The study includes interventional protocol of 6 weeks. The sessions will be given on 2 alternate days making it a total of 12 sessions and then follow up.

Other: Conventional Therapy Group

Interventions

Blood flow Restriction/Resistance Training OTHER

During each exercise, only blood flow in the involved leg was restricted using an aneroid sphygmomanometer. Prior to exercise the cuff was placed on the most proximal portion of the limb and limb occlusion pressure (LOP) was calculated in the body position that the Blood flow Restriction (BFR) stimulus would be applied. Blood Flow Restriction BFR pressure was set at 50% occlusion. Resistance applied for 1 minute (60 sec) with 30 % load of 1 repetition maximum. Subjects will receive treatment bilaterally. Participants will perform exercises 2 sets with 15 repetitions through 0 to 90 degrees.

Resistance exercise group

Conventional Therapy Group OTHER

Resistance applied for 1 minute (60 sec) with 30 % load of 1 repetition maximum. Subjects will receive treatment bilaterally.participants will perform 2 sets with 15 repetitions in (0 to 90 degree.)

Conventional Therapy Group

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Pain : Subjects having unilateral or bilateral pain
• Pain type : subjects having chronic pain
• Includes diagnosed cases of knee osteoarthritis
• grades 2-3 according to the Kellgren and Lawrence method of grading
• Includes knee osteoarthritis patients with lateral tracking of patella which will assessed through Q angle test

You may not qualify if:

• Any other orthopaedic or neurological condition of hip and knee
• Sign and symptoms of lower motor neuron disease
• Current use of medication
• Radiculopathy
• Fracture
• Malignancy
• Thromboembolism
• Decreased range of motion

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (2)

Gulberg Medical Complex

Islamabad, Federal, 44000, Pakistan

Location

Medcity International Hospital

Islamabad, Federal, 44000, Pakistan

Location

MeSH Terms

Conditions

Osteoarthritis, Knee; Hypertrophy; Osteoarthritis

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Saad Rauf, Master

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 17, 2021
• First Posted: September 28, 2021
• Study Start: October 10, 2021
• Primary Completion: February 11, 2022
• Study Completion: February 11, 2022
• Last Updated: March 23, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share

Locations

PA (2)