Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia:

NCT05055895 | Unknown

• 1 other identifier: 2020-383
• Study Type: observational
• Target: 450
• Locations: 1 country
• Sites: 1

Brief Summary

Drugs with anticholinergic properties are commonly prescribed to older persons despite growing evidence of their significant adverse effects. However, limited data are available concerning their contribution to time of onset of delirium. This study aimed to determine the potential association of higher anticholinergic burden to early-onset of delirium superimposed dementia in the older adult.

Conditions

Delirium; Anticholinergic Adverse Reaction; Alzheimer Disease

Outcome Measures

Primary Outcomes (1)

• Time onset of delirium superimposed dementia

  First attack of delirium onset

  12 month

Study Arms (2)

early onset deliryum on dementia

It was earlier than The median time of onset of delirium superimposed dementia

Drug: Anticholinergic burden

Delirium on dementia (normal)

It was equal or later than The median time of onset of delirium superimposed dementia

Drug: Anticholinergic burden

Interventions

Anticholinergic burden DRUG

The anticholinergic burden (ACB) was assessed using the Anticholinergic Burden Scale. Higher ACB was described as equal or higher than 1.

Delirium on dementia (normal); early onset deliryum on dementia

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All participiants enrolled from outpaitent clinic and underwent by comprehesive geriatric asssessment. Delirium and dementia status was assessed by the criteria of confusion assessment method (CAM) and DSM-4 or DSM-5 respectively.

You may qualify if:

• years and older and diagnosis or fellow-up of Alzhemier dementia in outpatient clinic.

You may not qualify if:

• The patients with a history of other than Alzhemier dementia or neurodegenerative disease (epilepsy, multiple sclerosis, Parkinson disease, etc.), terminal illness (malignancy, advanced organ failure) were excluded.

Sponsors & Collaborators

• Gulhane Training and Research Hospital: lead

Study Sites (1)

Gulhane training and research hospital

Ankara, 06670, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Delirium; Alzheimer Disease

Condition Hierarchy (Ancestors)

Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Dementia; Brain Diseases; Central Nervous System Diseases; Tauopathies; Neurodegenerative Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Geriatric

Study Record Dates

• First Submitted: September 15, 2021
• First Posted: September 24, 2021
• Study Start: January 1, 2005
• Primary Completion: June 1, 2021
• Study Completion: December 1, 2022
• Last Updated: September 24, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)