Long-life Endurance Exercise and Healthy Aging

NCT05053282 | Unknown

• 1 other identifier: 305041X157
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The project aims to explore the mechanisms by which lifelong exercise can promote healthy aging and slow down the negative impact of aging on the muscular system, immunity and the circadian system. The main goal of the project is to investigate the effect of lifelong endurance exercise on physical fitness, body composition, bone density and selected hormonal, biochemical, histological and molecular indicators of metabolic health and circadian clock function based on blood, immune cell and skeletal muscle tissue analyses in volunteers differentiated by age and weekly volume of physical activity. It is hypothesized that lifelong endurance exercise may have beneficial effects on the circadian system stability and many, but not all health outcomes. Osteopenia/osteoporosis and low-grade malnutrition may be more prevalent in the group of endurance-trained senior runners. In order to achieve the above research aims, sixty male subjects in total will be recruited according to inclusion and exclusion criteria. Four groups of subjects will differ according to their age and physical activity levels:

• a group of endurance-trained seniors (age range 65 - 75 year old, n=15) ● a group of sedentary seniors (age range 65 - 75 year old, n=15)
• a group of well endurance-trained young men (age range 20 - 30 year old, n=15) ● a group of sedentary young men (age range 20 - 30 year old, n=15). Subjects must meet the following inclusion criteria:
• for athletes' groups: defined as more than 150 minutes of running activity per week; for young athletes at least 3 years and for master athletes at least 15 years history of running.
• for groups less active than recommended: no history of regular physical activity training and no more practice than 150 minutes of moderate or 75 minutes of vigorous intensity per week.

Conditions

Aging

Keywords

aging; exercise; endurance running; circadian; inflammation; bone density

Outcome Measures

Primary Outcomes (1)

• maximal oxygen consumption

  peak oxygen consumption normalised to body mass (mL/kg/min), measured through a graded cycling ergometry

  cross-sectional, one-point assessment over 1 day

Secondary Outcomes (8)

• body composition

  cross-sectional, one-point assessment over 1 day

• bone mineral content

  cross-sectional, one-point assessment over 1 day

• bone mineral density

  cross-sectional, one-point assessment over 1 day

• maximum isometric muscle strength

  cross-sectional, one-point assessment over 1 day

• maximum isometric muscle torque development

  cross-sectional, one-point assessment over 1 day

Other Outcomes (9)

• skeletal muscle tissue - (PCR) RNA expression

  cross-sectional, one-point assessment over 1 day

• biochemical biomarkers of nitrogen compounds

  cross-sectional, one-point assessment over 1 day

• biochemical biomarkers of lipid and carbohydrate metabolism

  cross-sectional, one-point assessment over 1 day

Study Arms (4)

master endurance athletes

men aged 65 to 75 with more than 150 minutes of running activity per week at least 15 years history of running

Other: endurance running exercise

elderly sedentary

men aged 65 to 75 with no history of regular physical activity training and no more practice than 150 minutes of moderate or 75 minutes of vigorous intensity per week according the ACSM recommendations

young endurance athletes

men aged 20 to 30 with more than 150 minutes of running activity per week at least 3 years history of running

Other: endurance running exercise

young sedentary

men aged 20 to 30 with no history of regular physical activity training and no more practice than 150 minutes of moderate or 75 minutes of vigorous intensity per week according the ACSM recommendations

Interventions

endurance running exercise OTHER

regular competitive or non-competitive running of medium and/or high intensity with the duration at least 20 minutes per session

master endurance athletes; young endurance athletes

Eligibility Criteria

• Age: 20 Years - 75 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Inhabitants of Bratislava city (Slovakia) and those living within one hour drive by car from the laboratory (Faculty of Physical Education and Sport, Comenius University in Bratislava)

You may qualify if:

• for athletes' groups (master - 65 - 75 years old, and young athletes - 20 - 30 years old)
• more than 150 minutes of running activity which is by ACSM considered as vigorous intensity of endurance running for young athletes at least 3 years and for master athletes at least 15 years
• body mass index (BMI index) - range 18.5-30 kg/m2
• for groups less active than recommended (sedentary young and elderly)
• no history of regular physical activity training and no more practice than 150 minutes of moderate or 75 minutes of vigorous intensity per week
• body mass index (BMI index) - range 18.5-30 kg/m2

You may not qualify if:

• recent or current infection
• malignant disease
• uncontrolled hypertension (higher than 160 / 95mmHG)
• congestive heart failure (NYHA grade III and IV)
• unstable angina pectoris
• recent myocardial infarction (during the last 6 months)
• severe cardiac arrhythmia (anamnestic)
• chronic obstructive pulmonary disease
• presence of severe pulmonary, pleural or pericardial disease
• severe asthma
• recent sudden stroke (during the last 6 months)
• epilepsy
• insulin-dependent diabetes mellitus
• unstable bone lesions with a high risk of fractures
• other chronic diseases, at the discretion of the responsible doctor

Sponsors & Collaborators

• Comenius University: lead
• Physiko- und Rheumatherapie Gesellschaft m.b.H.: collaborator
• University of Padova: collaborator
• University of Roma La Sapienza: collaborator
• University of Primorska: collaborator

Study Sites (1)

Comenius University in Bratislava, Faculty of physical education and sport Bratislava, Slovakia

Bratislava, 814 99, Slovakia

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

whole blood white cells blood serum and plasma skeletal muscle tissue from m. vastus medialis saliva

MeSH Terms

Conditions

Motor Activity; Inflammation

Condition Hierarchy (Ancestors)

Behavior; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Ján Cvečka, PhD.

  Comenius University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Milan Sedliak, assoc. prof.

CONTACT

+421907247021; milan.sedliak@uniba.sk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 3, 2021
• First Posted: September 22, 2021
• Study Start: September 1, 2020
• Primary Completion: June 30, 2022
• Study Completion: September 30, 2022
• Last Updated: September 22, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

SL (1)