Daily Activity Study of Health: Increasing Physical Activity in Aging

NCT04315363 | Completed Results

• 2 other identifiers: 19-06-05P30AG048785
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

In this six-week behavioral intervention, sedentary older adults will receive daily health messaging via their smart phone to better understand their daily activities and emotions. Participants undergo structural and functional brain imaging before and after the intervention along with measures of their behavioral, emotional and thinking functions.

Conditions

Aging

Keywords

motivation

Outcome Measures

Primary Outcomes (1)

• Change in Sedentary Behavior (Average Hour/Day)

  This metric quantifies the change in the average amount of time spent sedentary each day in hours, from the baseline period to the 6-week follow-up period. It is a marker of time spent inactive.

  Baseline; 6-week

Secondary Outcomes (1)

• Change in Moderate-to-Vigorous Physical Activity

  Baseline; 6-week

Study Arms (2)

Intervention

EXPERIMENTAL

Brain MRI and Motivational Behavioral Intervention

Behavioral: Motivational MRI and Behavioral Intervention

Active control

ACTIVE COMPARATOR

Brain MRI and Control Behavioral Intervention

Behavioral: Control MRI and Behavioral Intervention

Interventions

Motivational MRI and Behavioral Intervention BEHAVIORAL

Motivational messaging delivered during a functional brain MRI scan and with daily messaging

Intervention

Control MRI and Behavioral Intervention BEHAVIORAL

Control messaging delivered during a functional brain MRI scan and with daily messaging

Active control

Eligibility Criteria

• Age: 60 Years - 95 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age range 60-95
• Not exercising more than 150 minutes of moderate/vigorous intensity per week AND sitting more than 8 hours per day
• No contraindications to MRI (if opting for MRI)
• Being able to speak English fluently
• Body Mass Index (BMI) between 20 and 40
• Normal or corrected-normal vision based on the minimal 20/20 standard
• Ambulatory without severe pain or the assistance of walking devices
• No diagnosis of a neurological disease
• Regular access to a computer with internet or smartphone

You may not qualify if:

• Primary care physician does not approve additional physical activity
• Inability to ambulate without assistive device
• Any unstable medical condition
• Current diagnosis of a Diagnostic and Statistical Manual of Mental Disorders (DSM-V) Axis I or II disorder including Major Depression
• History of major psychiatric illness including schizophrenia (not including general anxiety disorder or depression)
• Current treatment for cancer - except non-melanoma skin
• Neurological condition (multiple sclerosis, Parkinson's disease, dementia, mild cognitive impairment) or brain injury (traumatic or stroke)
• Current alcohol or substance abuse
• Current treatment for congestive heart failure, angina, uncontrolled arrhythmia, deep vein thrombosis or other cardiovascular event
• Myocardial infarction, coronary artery bypass grafting, angioplasty or other cardiac condition in the past year
• Not passing the Telephone Interview of Cognitive Status (TICS) as normal
• Use of any anti-psychotic, anti-depressant, anti-anxiety, and attention deficit disorder (ADD/ADHD) medications.

Sponsors & Collaborators

• Northeastern University: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

Northeastern University

Boston, Massachusetts, 02120, United States

Location

Related Publications (1)

• Ai M, Morris TP, Ordway C, Quinonez E, D'Agostino F, Whitfield-Gabrieli S, Hillman CH, Pindus DM, McAuley E, Mayo N, de la Colina AN, Phillips S, Kramer AF, Geddes M. The Daily Activity Study of Health (DASH): A pilot randomized controlled trial to enhance physical activity in sedentary older adults. Contemp Clin Trials. 2021 Jul;106:106405. doi: 10.1016/j.cct.2021.106405. Epub 2021 May 1.

  PMID: 33945886 BACKGROUND

MeSH Terms

Interventions

Behavior Therapy

Intervention Hierarchy (Ancestors)

Psychotherapy; Behavioral Disciplines and Activities

Limitations and Caveats

Given that the trial was conducted during lockdowns due to the COVID-19 pandemic, the original brain imaging MRI outcomes were modified. Intervention delivery was remote due to in-person data collection restrictions.

Results Point of Contact

• Title: Meishan Ai
• Organization: Northeastern University

ai.me@northeastern.edu

858-265-7288

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Affiliate Associate Professor

Study Record Dates

• First Submitted: February 26, 2020
• First Posted: March 19, 2020
• Study Start: November 13, 2020
• Primary Completion: October 1, 2022
• Study Completion: September 30, 2023
• Last Updated: February 29, 2024
• Results First Posted: February 29, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)