Effect of Ultrasound-guided Left Stellate Ganglion Block on Rapid Recovery in Patients With Liver Lobectomy and Its Mechanism

NCT05042583 | Unknown

• 1 other identifier: 1
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Lobe resection of complex process Traumatic big liver door block causes the body's nervous system very excited or inhibit the endocrine system, immune excessive activation of inflammatory cells, triggering and cause dysfunction of the immune inflammatory reaction, of patients with injury of tissues and organs and affect its repair, increase the risk of complications after liver resection, affected lobe resection in patients with postoperative rapid recovery. Stellate ganglion block has been widely used in the treatment of various systemic diseases due to its advantages of simple operation and obvious effect. SGB has broad application prospects and can promote postoperative recovery of patients undergoing major surgery, but its effect on the rapid recovery of patients undergoing liver lobectomy and its mechanism remain to be further explored.

Conditions

Left Stellate Ganglion Block on Rapid Recovery; Possible Molecular Mechanism of Left Stellate Ganglion Block

Keywords

Guided by ultrasound; Stellate ganglion block; hepatectomy; ERAS

Outcome Measures

Primary Outcomes (3)

• Postoperative complications

  pulmonary infection, oxygenation injury, arrhythmia, bleeding, intestinal paralysis, incision infection, renal insufficiency, cognitive dysfunction, etc.

  Within one week after surgery

• mortality rate

  mortality rate

  Within 30 days after surgery

• Plasma concentrations of IL-6,IL-10 and TNF-α

  Plasma concentrations of IL-6,IL-10 and TNF-α were measured before operation, 6 h after operation, 24 h after operation, and 72 h after operation

  Within three days of the surgery

Study Arms (2)

experimental group

EXPERIMENTAL

The experimental group was injected with 0.5% ropivacaine 6ml

Procedure: Stellate ganglion block

Control group

PLACEBO COMPARATOR

control group was injected with 6ml normal saline.

Procedure: Stellate ganglion block

Interventions

Stellate ganglion block PROCEDURE

The probe direction was 30-45 degrees from the sagittal plane of the neck. The anterior nodules of the transverse process of the sixth cervical vertebra were displayed. The important anatomical structures were distinguished, and the internal carotid artery and longus cervical muscle were observed. A 25G, 6cm puncture needle was used with the tip beveled downward, and the needle path and tip were shown under ultrasound. The tip reached the high-echo sieve structure between the carotid artery and longus cervical muscle, and the drug solution was injected after withdrawal without blood and gas . The experimental group was injected with 6ml 0.5% ropivacaine.

Control group; experimental group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

Sponsors & Collaborators

• Zhonghua Chen,MD: lead
• China (Zhejiang) Health technology RESEARCH and development and transformation platform: collaborator

Study Sites (1)

Shaoxing People's Hospital

Shaoxing, Zhejiang, 312000, China

RECRUITING

Related Publications (1)

• Lao WL, Sang S, Huang LC, Yi SH, Guo MC, Dong HM, Zhou GZ, Chen ZH. Effect of ultrasound-guided stellate ganglion block on inflammatory cytokines and postoperative recovery after partial hepatectomy: a randomised clinical trial. BMC Anesthesiol. 2024 Jan 2;24(1):7. doi: 10.1186/s12871-023-02392-7.

  PMID: 38166634 DERIVED

Central Study Contacts

zhonghua chen, master's degree

CONTACT

13625751526; chenbeijing116@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Neither the experimenters nor the participants knew whether they were getting an experimental drug or a placebo. In this way, the description of the therapeutic effects and adverse reactions of the subjects, as well as the record of the various reactions of the experimenters, can be as objective as possible.
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: associate chief physician

Model Details: Sixty patients with liver lobectomy were selected and divided into two groups according to random number table method: experimental group and control group., with 30 cases in each group. All enrolled patients signed informed consent. Control group: The control group was injected with physiological saline 6ml for stellate ganglion block.Experimental group: The experimental group was injected with 0.5% ropivacaine 6ml for stellate ganglion block.

Study Record Dates

• First Submitted: September 4, 2021
• First Posted: September 13, 2021
• Study Start: January 1, 2021
• Primary Completion: August 1, 2023
• Study Completion: December 1, 2023
• Last Updated: January 13, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)