Brain Network Mechanisms Causally Underlying Human Decisions Revealed by Brain Stimulation and Functional MRI
1 other identifier
interventional
1,800
0 countries
N/A
Brief Summary
We will examine how stimulation of specific brain areas with transcranial magnetic stimulation (TMS) or transcranial electric stimulation (tES) changes specific aspects of behavior and brain activity, in order to test hypotheses about brain behavior relationships (basic research).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2021
Longer than P75 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 16, 2021
CompletedFirst Posted
Study publicly available on registry
August 30, 2021
CompletedStudy Start
First participant enrolled
September 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2025
CompletedAugust 30, 2021
August 1, 2021
4.1 years
August 16, 2021
August 23, 2021
Conditions
Outcome Measures
Primary Outcomes (4)
Speed of Behaviour
Reaction time in miliseconds
0-60 minutes after stimulation
Accuracy of Behaviour
Accuracy in percent correct
0-60 minutes after stimulation
Cognitive Function driving Behaviour
Parameter of Model describing cognitive function governing behaviour
0-60 minutes after stimulation
Brain activity
BOLD contrast in fMRI data
0-60 minutes after stimulation
Study Arms (2)
Stimulation
EXPERIMENTALTMS or tES, depending on experiment
Sham
SHAM COMPARATORCorresponding sham TMS or tES
Interventions
Eligibility Criteria
You may qualify if:
- between 18 and 80 years of age (whereby for most studies the majority of recruited participants will be between 18 and 40 years of age)
You may not qualify if:
- inability to understand the instructions and insufficient knowledge of the project language
- Internal electronic and/or metallic objects in the head, neck, or shoulders (e.g. artificial cochleae, deep brain stimulators, medical pumps, shrapnel, metallic splinters due to accidents during metal welding)
- One or more epileptic fits in the participant or a first-degree relative
- Vascular, traumatic, tumoral, infectious, or metabolic brain damage
- Use of medication that significantly alters cortical excitability
- Acute sleep deprivation or withdrawal from alcohol
- pregnancy
- to reduce bias, students of psychology or economics can be excluded if there is a possibility that they are familiar with the relevant paradigm.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Christian Rufflead
MeSH Terms
Conditions
Interventions
Study Officials
- PRINCIPAL INVESTIGATOR
Christian Ruff, PhD
University of Zurich
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Prof. Dr.
Study Record Dates
First Submitted
August 16, 2021
First Posted
August 30, 2021
Study Start
September 1, 2021
Primary Completion
September 30, 2025
Study Completion
September 30, 2025
Last Updated
August 30, 2021
Record last verified: 2021-08