NCT05018741

Brief Summary

The study retrospectively reviewed the medical records of patients who received adult liver transplantation in Changhua Christian hospital from 2002 to 2019. We collected their personal data about liver disease, laboratory data about liver function, pre-transplant evaluation and post-transplant outcome. We investigate what prognostic factors may contribute a good survival outcome, and improve our clinical practice.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
600

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2002

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2002

Completed
18 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2019

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

August 22, 2021

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 24, 2021

Completed
Last Updated

August 24, 2021

Status Verified

August 1, 2021

Enrollment Period

18 years

First QC Date

August 22, 2021

Last Update Submit

August 22, 2021

Conditions

Liver DiseasesLiver Transplant; Complications

Keywords

liver transplantationchronic liver diseaseviral hepatitisalcoholic liver disease

Outcome Measures

Primary Outcomes (1)

  • number of participants with morbidity and mortality after surgery

    post-operative complications which requiring interventions, related to organ failure and hospital mortality

    upto one month after surgery

Secondary Outcomes (1)

  • long-term survival rate

    upto 5 years after surgery

Study Arms (1)

Liver transplant

Procedure: liver transplantation

Interventions

liver transplantationPROCEDURE

liver transplantation for chronic liver disease or acute liver failure

Liver transplant

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients with acute liver failure or chronic liver disease due to different etiologies received liver transplantation

You may qualify if:

  • patients who received adult liver transplantation in Changhua Christian hospital from 2002 to 2019

You may not qualify if:

  • patients who did not have suitable donor for liver transplantation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (3)

  • Lee SG, Hwang S, Moon DB, Ahn CS, Kim KH, Sung KB, Ko GY, Park KM, Ha TY, Song GW. Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large-volume center. Liver Transpl. 2008 Jul;14(7):935-45. doi: 10.1002/lt.21445.

    PMID: 18581465BACKGROUND

  • Chang Y, Cho Y, Lee JH, Lee YB, Cho EJ, Yu SJ, Sinn DH, Kim BH, Kim SH, Yi NJ, Lee KW, Kim JM, Park JW, Kim YJ, Yoon JH, Joh JW, Suh KS. Comparison of Models for Tumor Recurrence after Liver Transplantation for the Patients with Hepatocellular Carcinoma: A Multicenter Long-Term Follow-Up Study. Cancers (Basel). 2019 Sep 3;11(9):1295. doi: 10.3390/cancers11091295.

    PMID: 31484287BACKGROUND

  • Mazzaferro V, Llovet JM, Miceli R, Bhoori S, Schiavo M, Mariani L, Camerini T, Roayaie S, Schwartz ME, Grazi GL, Adam R, Neuhaus P, Salizzoni M, Bruix J, Forner A, De Carlis L, Cillo U, Burroughs AK, Troisi R, Rossi M, Gerunda GE, Lerut J, Belghiti J, Boin I, Gugenheim J, Rochling F, Van Hoek B, Majno P; Metroticket Investigator Study Group. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. Lancet Oncol. 2009 Jan;10(1):35-43. doi: 10.1016/S1470-2045(08)70284-5. Epub 2008 Dec 4.

    PMID: 19058754RESULT

MeSH Terms

Conditions

Liver DiseasesLiver Diseases, Alcoholic

Interventions

Liver Transplantation

Condition Hierarchy (Ancestors)

Digestive System DiseasesAlcohol-Induced DisordersAlcohol-Related DisordersSubstance-Related DisordersChemically-Induced Disorders

Intervention Hierarchy (Ancestors)

Tissue TransplantationCell- and Tissue-Based TherapyBiological TherapyTherapeuticsDigestive System Surgical ProceduresSurgical Procedures, OperativeOrgan TransplantationTransplantation

Study Officials

  • Yao-Li Chen

    Department of General Surgery, Changhua Christian Hospital, Changhua, Taiwan

    STUDY CHAIR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 22, 2021

First Posted

August 24, 2021

Study Start

January 1, 2002

Primary Completion

December 31, 2019

Study Completion

December 31, 2019

Last Updated

August 24, 2021

Record last verified: 2021-08

Data Sharing

IPD Sharing
Will not share