NCT05018351

Brief Summary

Adults with psychiatric disabilities get sick and die 20 to 30 years younger than same-age peers, with even greater disparities occurring when the person is from a low SES or of color. Factors explaining this difference are complex and include genetic comorbidity, iatrogenic effects of medication, life choices, and life consequences. These factors are worsened by service disparities which are often fragmented in the public health system. Peer navigators are part of a program in which providers escort people with psychiatric disabilities around the fragmented system to meet their health and wellness goals, often a demanding task for the person who has needs addressed at clinics, labs, and pharmacies spread across an urban area. Navigators are peers because they have lived experience of recovery and are often from similar ethnic groups. A community-based participatory research program supported by NIMHD and PCORI developed a peer navigator program specific to the needs of people with psychiatric disabilities. Results of two small pilots funded by NIMHD and PCORI showed the Peer Navigator Program (PNP) led to significant improved service engagement which corresponded with better health, recovery, and quality of life. The studies included fidelity measurement which showed peer navigators conducting the intervention at high levels of fidelity. The current research is an efficacy study with a more fully powered test of PNP versus treatment as usual, which is integrated care (TAU-IC). The investigators aim to recruit 300 adults with psychiatric disability who wish to improve physical health/wellness through peer health navigation randomized to TAU-IC or TAU-IC plus PNP. Individuals will participate in assigned interventions as part of 8-month cohorts with data being obtained at baseline, 4, 8, and 12 months. Data will include personal descriptors (demographics, diagnosis, life consequences report), outcomes (service engagement, physical symptoms, blood pressure, recovery, and quality of life), mediators (personal empowerment, self-determination, and perceived relationship for recovery), and process measures (fidelity, feasibility, and acceptability). Investigators hypothesize that those in PNP intervention will have improved outcomes over the integrated care as usual. A cost-benefit analysis will seek to model impact based on quality-adjusted life years. Larger effect sizes will permit post hoc identification of how PNP effects vary by participant characteristics such as ethnicity and gender.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
354

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started May 2021

Longer than P75 for not_applicable

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 17, 2021

Completed
15 days until next milestone

First Submitted

Initial submission to the registry

June 1, 2021

Completed
3 months until next milestone

First Posted

Study publicly available on registry

August 24, 2021

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2025

Completed
Last Updated

April 8, 2022

Status Verified

March 1, 2022

Enrollment Period

4.3 years

First QC Date

June 1, 2021

Last Update Submit

March 30, 2022

Conditions

Keywords

Mental DisorderPhysical IllnessPsychiatric DisabilityPeer NavigatorSerious Mental IllnessPhysical Health

Outcome Measures

Primary Outcomes (2)

  • Change from Baseline in 36-Item Short Form Health Survey (SF-36) Scores at Months 4, 8, and 12

    Assesses change in participants' health status and health-related quality of life over the 12 months of the study along 9 domains (physical functioning, role limitations due to physical health, role limitations due to emotional problems, energy/fatigue, emotional well-being, social functioning, pain, and general health). Each of the aforementioned scales have a range of scores from 0 (minimum) - 100 (maximum), with higher scores indicating better outcomes (e.g., a score of 100 on the physical functioning scale indicates no problems with physical functioning). The investigators will evaluate change along all 9 domains. Change = (Month 4 Score - Baseline), (Month 8 Score - Baseline), (Month 12 Score - Baseline)

    Baseline, 4 months, 8 months, 12 months

  • Change from Baseline in Texas Christian University Health Form (TCU-HLTHFORM) Scores at Months 4, 8, and 12

    This 24-item measure will assess respondents' experience with physical health problems (e.g., stomach problems or ulcers, bladder infections) and mental health problems (e.g., tired for no good reason, nervous) over the 12 months of the study. The TCU-HLTHFORM assesses health along two domains: psychological distress and physical health. The psychological distress scale scores range from 10 (minimum) to 5 (maximum), with scores of 25-29 indicating high levels of distress, and scores of 30-50 indicating very high levels of distress, thus worse outcomes. The physical health items range from 11 (minimum) to 55 (maximum). Higher scores on these items indicate higher levels of physical health problems, thus worse outcomes. Change = (Month 4 Score - Baseline), (Month 8 Score - Baseline), (Month 12 Score - Baseline)

    Baseline, 4 months, 8 months, 12 months

Secondary Outcomes (10)

  • Change from Baseline in Quality of Life Scale (QLS) Scores at Months 4, 8, and 12

    Baseline, 4 months, 8 months, 12 months

  • Change from Baseline in Recovery Assessment Scale-Revised (RAS-R) Scores at Months 4, 8, and 12

    Baseline, 4 months, 8 months, 12 months

  • Change from Baseline in Systolic and Diastolic Blood Pressure at Months 4, 8, and 12

    Baseline, 4 months, 8 months, 12 months

  • Change from Baseline in Center for Epidemiologic Studies Depression Scale-Depression 10-item version (CES-D 10) Scores at Months 4, 8, and 12

    Baseline, 4 months, 8 months, 12 months

  • Change from Baseline in Generalized Anxiety Disorder-7 (GAD-7) Scores at Months 4, 8, and 12

    Baseline, 4 months, 8 months, 12 months

  • +5 more secondary outcomes

Study Arms (2)

Treatment as Usual-Integrated Care (TAU-IC)

ACTIVE COMPARATOR

Participants in this arm will receive integrated care from their usual provider, which is treatment as usual. Integrated care is mental health specialty and general medical care providers working together to address the physical and behavioral health care needs of patients. One-half of research participants will be randomized to integrated care alone.

Behavioral: Integrated Care

Peer Navigator Program (PNP)

EXPERIMENTAL

Peer navigators will meet individually and face-to-face with research participants in time and places convenient to the person as needed. Specific practices are determined by the research participant with the peer navigator and may include: * scheduling and attending healthcare appointments; * partnering with participant on tasks that arise from appointments; * health-related goal setting; and * taking action-steps toward health-related goals.

Behavioral: Peer Navigation

Interventions

Integrated CareBEHAVIORAL

Participants receive integrated physical and mental health care from their usual provider.

Treatment as Usual-Integrated Care (TAU-IC)
Peer NavigationBEHAVIORAL

Peer navigators will meet individually and face-to-face with participants to address their health and weight goals (i.e. working on health-related goals, attending health care appointments. and facilitating follow-up activities related to healthcare appointments).

Peer Navigator Program (PNP)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age 18 or older
  • Serious mental illness (as indicated by disability)
  • A desire to improve their physical health/wellness and prevent disease through peer health navigation
  • Willing to attend
  • Active Thresholds member residing in the catchment area (Chicago South Side)

You may not qualify if:

  • Currently receiving services from a peer support specialist to work on health-related goals
  • Currently receiving Assertive Community Treatment services
  • Not an active Thresholds member
  • Does not reside in the catchment area (Chicago South Side)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Thresholds

Chicago, Illinois, 60613, United States

RECRUITING

Illinois Institute of Technology

Chicago, Illinois, 60616, United States

RECRUITING

MeSH Terms

Conditions

Mental Disorders

Interventions

Delivery of Health Care, Integrated

Intervention Hierarchy (Ancestors)

Delivery of Health CarePatient Care ManagementHealth Services AdministrationHealth Care Quality, Access, and Evaluation

Study Officials

  • Patrick W Corrigan, PsyD

    Illinois Institute of Technology

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Patrick W Corrigan, PsyD

CONTACT

Carla D Kundert, MS

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Persons are randomly assigned to receive either: A) treatment as usual (TAU-IC), which is Integrated Care services with Thresholds, OR B) peer navigator program (PNP), which includes in-vivo support with managing physical health and wellness at least weekly
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 1, 2021

First Posted

August 24, 2021

Study Start

May 17, 2021

Primary Completion

September 1, 2025

Study Completion

September 1, 2025

Last Updated

April 8, 2022

Record last verified: 2022-03

Data Sharing

IPD Sharing
Will share

Results will be available to researchers and service agencies, with quantitative data available from an expected 300 participants with psychiatric disabilities who report a desire to improve physical health/wellness and prevent disease through peer navigation. No identifying information will be connected to the data and investigators do not believe that there is a possibility of deductive disclosure of subjects with unusual characteristics. Regardless, to ensure the protection of the human subjects involved in this research, investigators will make the data and associated documentation available to users only under a data-sharing agreement. Notice of available data will be posted in appropriate arenas including websites for the project: www.chicagohealthdisparities.org and www.ncse1.org.

Time Frame
Data will be available on 08-31-2025.
Access Criteria
To ensure the protection of the human subjects involved in our research, investigators will make the data and associated documentation available to users only under a data-sharing agreement that provides for: (1) a commitment to using the data only for research purposes and not to identify any individual participant; (2) a commitment to securing the data using appropriate computer technology; and (3) a commitment to destroying or returning the data after analyses are completed.
More information

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