Risk Underlying Rural Areas Longitudinal Cohort Study (RURAL) Heart and Lung Study

NCT05006729 | Recruiting DMC

• 3 other identifiers: H-42363U01HL146382HSC20230132H
• Study Type: observational
• Target: 4,600
• Locations: 1 country
• Sites: 1

Brief Summary

The University of Texas Health Science Center at San Antonio (UTHSCSA) will serve as the site for the RURAL Study Coordinating Center, led by PI Vasan Ramachandran, MD. The primary function of the Study Coordinating Center (SCC) is to serve as an administrative liaison between all of the RURAL study's cores. The SCC schedules, facilitates, and hosts, all RURAL meetings including preparation for Observational Study Monitoring Board (OSMB) meetings, and maintains direct communication with the study's program officers at NHLBI. The SCC monitors the overall progress of RURAL and keeps all RURAL cores abreast of study updates through meetings, emails, newsletters. It also maintains the official RURAL website and serves as an administrator for investigators seeking to collaborate with RURAL through the submission of Ancillary Studies. The SCC will have no direct interaction with any participants, nor will it have access to identifiable data.

Conditions

Rural Health; Pulmonary Disease; Heart Diseases

Keywords

Risk factors for heart disease; Risk factors for lung disease; Psychosocial factors; Familial factors; Economic factors; Mobile examination unit (MEU); Alabama; Kentucky; Louisiana; Mississippi

Outcome Measures

Primary Outcomes (2)

• Risk factors for lung disease in rural areas

  5 years

• Risk factors for heart disease in rural areas

  5 years

Secondary Outcomes (2)

• Pulmonary function

  5 years

• Heart function

  5 years

Study Arms (1)

RURAL cohort study

A longitudinal research project in ten rural counties in Alabama, Kentucky, Louisiana, and Mississippi enrolling approximately 4,600 participants from these communities, examining several different aspects of their health, including heart and lung function.

Eligibility Criteria

• Age: 25 Years - 64 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The Risk Underlying Rural Areas Longitudinal (RURAL) Cohort is a health research project in ten rural counties throughout Alabama, Kentucky, Louisiana, and Mississippi of residents 25-64 years of age.

You may qualify if:

• Be a resident of specific counties in Alabama, Kentucky, Louisiana, and Mississippi
• Have resided in the specific county for the past two years and plan to reside at the residence for the next two years
• Speak English or Spanish

You may not qualify if:

• Currently incarcerated or institutionalized
• Currently in hospice care with a terminal illness and less than 6 month life expectancy
• Being actively treated for cancer

Sponsors & Collaborators

• The University of Texas Health Science Center at San Antonio: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

University of Alabama

Birmingham, Alabama, 35294, United States

RECRUITING

Related Links

• The RURAL (Risk Underlying Rural Areas Longitudinal) Cohort Study aims to address critical gaps in our knowledge of heart and lung disorders in rural counties in the southeastern US.

Biospecimen

Retention: SAMPLES WITH DNA

Biospecimens will be de-identified. All phenotype and genotype information associated with the biospecimens may be shared in accordance with the NHLBI Biologic Specimen and Data Repositories Information Coordinating Center (BioLINCC) data repository sharing policies, in which investigators may obtain de-identified and limited data sets via formal agreements.

MeSH Terms

Conditions

Lung Diseases; Heart Diseases

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases; Cardiovascular Diseases

Study Officials

• Vasan Ramachandran, MD

  University of Texas Health Science Center San Antonio

  STUDY DIRECTOR

• Suzanne Judd, PhD

  University of Alabama at Birmingham

  PRINCIPAL INVESTIGATOR

• Paul Targonski, MD PhD

  University of Virginia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Vasan Ramachandran, MD

CONTACT

(210) 450 7355; vasan@uthscsa.edu

Rachael Langey, BS

CONTACT

(210) 450 7355; langey@uthscsa.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dean School of Public Health

Study Record Dates

• First Submitted: August 9, 2021
• First Posted: August 16, 2021
• Study Start: January 15, 2021
• Primary Completion: April 1, 2026
• Study Completion: April 1, 2026
• Last Updated: May 16, 2025

Record last verified: 2025-05

Locations

US (1)