Prone Position During ECMO in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Hypoxaemic Patient

NCT04995289 | Completed

• 1 other identifier: MohammedVIUH
• Study Type: observational
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: The main manifestation of COVID-19 pneumonia is acute respiratory distress syndrome (ARDS), which in some cases can be more severe than intubation, extracorporeal membrane venous oxygenation (VV-ECMO) to ensure hematosis. Despite support from VV-ECMO, some patients may remain hypoxemic. One possible therapeutic procedure for these patients is the application of the prone position. Objective: The main aim of this study was to investigate the modification of the PaO2/FiO2 ratio, the compliance of the respiratory system in VV-ECMO with refractory hypoxemia. The secondary objective was to evaluate the safety and feasibility of the inclined position for ECMO. Methods: the investigators reviewed the electronic records and lists of all 23 COVID-19 patients. were placed for the first time in PP with an average duration of 16 h . patient characteristics, pre-ECMO characteristics, ventilator/ECMO settings, and changes in ventilator/ECMO settings and blood gas analysis before and after PP.

Conditions

SARS CoV 2 Infection; Hypoxemic Respiratory Failure

Keywords

ECMO; ARDS; Prone position; COVID; compliance

Outcome Measures

Primary Outcomes (1)

• amelioration of PaO2/FiO2

  the investigators recoordeed Blood gas analysis before and after Prone position

  through study completion, an average of 1 yea

Interventions

Prone position on ECMO patient OTHER

blood gas analysis before and after PP

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

23 patients admitted to the intensive care unit of different genders and ethnicities were included.

You may qualify if:

• Clinical diagnosis of SARS COV 2 infection complicated by ARDS, and needed a VV ECMO.
• patient who presented refractory hypoxemia during VV ECMO.

You may not qualify if:

• patient who has received ECMO V-A or ECMO VV for reasons other than ARDS.

Sponsors & Collaborators

• Mohammed VI University Hospital: lead

Study Sites (1)

younes Oujidi

Berkane, 9999, Morocco

Location

MeSH Terms

Conditions

COVID-19; Respiratory Insufficiency; Patient Compliance

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Respiration Disorders; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 28, 2021
• First Posted: August 6, 2021
• Study Start: January 1, 2020
• Primary Completion: January 30, 2021
• Study Completion: January 30, 2021
• Last Updated: August 13, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share

Locations

MO (1)