A Multi-Center Diagnostic Stewardship Program to Improve Respiratory Culture Utilization in Critically Ill Children
BrighT STAR
3 other identifiers
observational
15
1 country
8
Brief Summary
The objective of this study is to evaluate implementation of diagnostic stewardship programs as a strategy to safely reduce antibiotic use, and to generate evidence and tools to support dissemination of diagnostic stewardship programs to a large and diverse group of hospitals.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started May 2021
Longer than P75 for all trials
8 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2021
CompletedFirst Submitted
Initial submission to the registry
July 28, 2021
CompletedFirst Posted
Study publicly available on registry
August 3, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
June 1, 2027
January 15, 2026
January 1, 2026
5.1 years
July 28, 2021
January 13, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Respiratory Culture Rate
Rate of endotracheal aspirate cultures; Change in respiratory cultures per 100 ventilator-days per month
up to 42 months
Secondary Outcomes (9)
Broad spectrum antibiotic use for ICU days >2 days
up to 42 months
New initiations - Broad spectrum antibiotic use for ICU days >2 days
up to 42 months
Mortality
up to 42 months
Length of ICU stay
up to 42 months
ICU readmission
up to 42 months
- +4 more secondary outcomes
Eligibility Criteria
ICU patient populations from units that develop and implement a quality improvement program to reduce respiratory culture use
You may qualify if:
- Institutions that plan to develop and implement a quality improvement program to reduce respiratory culture use in their Pediatric ICUs
You may not qualify if:
- Institutions that do not plan to develop and implement a quality improvement program to reduce respiratory culture use in their Pediatric ICUs
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (8)
Johns Hopkins Children's Center
Baltimore, Maryland, 21287, United States
Boston Children's Hospital
Boston, Massachusetts, 02115, United States
Children's Minnesota Hospital
Minneapolis, Minnesota, 55404, United States
Children's Hospital and Medical Center Omaha
Omaha, Nebraska, 68114, United States
Cleveland Clinic Children's Hospital
Cleveland, Ohio, 44106, United States
Le Bonheur Children's Hospital
Memphis, Tennessee, 38103, United States
Monroe Carell Jr. Children's Hospital
Nashville, Tennessee, 37232, United States
Dell Children's Medical Center
Austin, Texas, 78723, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Aaron Milstone, MD, MHS
Johns Hopkins University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 28, 2021
First Posted
August 3, 2021
Study Start
May 1, 2021
Primary Completion (Estimated)
June 1, 2026
Study Completion (Estimated)
June 1, 2027
Last Updated
January 15, 2026
Record last verified: 2026-01