Evaluation of Drug Overdose Poisoning Cases and Indications for ICU Admission

NCT04987801 | Unknown

• 1 other identifier: Drug overdose Evaluation
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

1. 1.Evaluation of drug overdose cases presented to Assiut university hospitals' adults and pediatric emergency departments (EDs) in one year period.
2. 2.Evaluation the role of intensive care unit (ICU) admission in these cases and possible scoring system for common groups of drug overdose.

Conditions

Drug Toxicity

Outcome Measures

Primary Outcomes (1)

• Evaluation of drug overdose cases presented to Assiut university hospitals' adults and pediatric E.D.

  A) Sheet includes the following items:- 1. Demographic data: Gender, Age, Marital status, Residence, Occupation, Special habits: smoking, drug abuse. 2. Data regarding overdosed drug: Type, form, dose and method of administration and mode of exposure 3. Symptoms of intoxication. B) Complete clinical examination C) Investigations: 1. Routine: ABG, ECG, Electrolytes 2. Specific Drug level, drug screening test in urine

  One year

Secondary Outcomes (1)

• Evaluation of the indications of intensive care unit (ICU) admission in drug overdose cases.

  one year

Interventions

Drug Toxicity OTHER

Patients who took over dose of Drugs

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who took over dose of Drugs

You may qualify if:

• Patients admitted or transferred to Assiut university hospitals' adults and pediatric EDs, with history of drug overdose intoxication within 24 hours prior to admission (single or multiple drug ingestions).
• Patients admitted or transferred to Assiut university hospitals' adults and pediatric EDs, with clinical signs and symptoms of drug overdose intoxication on examination.
• Patients admitted or transferred to Assiut university hospitals' adults and pediatric EDs, with blood and/or urine toxicology screens demonstrated the presence of non-prescribed, illicit drugs or inappropriately elevated levels of prescribed or over the-counter medications.

You may not qualify if:

• Patients admitted or transferred to Assiut university hospitals' adults and pediatric EDs, with history of drug overdose intoxication more than 24 hours.
• Patients admitted or transferred to Assiut university hospitals' adults and pediatric EDs, with history of non-drug intoxication, e.g insecticides poisoning

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Faculty of medicine

Asyut, Egypt

RECRUITING

Related Publications (8)

• Athavale V, Green C, Lim KZ, Wong C, Tiruvoipati R. Characteristics and outcomes of patients with drug overdose requiring admission to Intensive Care Unit. Australas Psychiatry. 2017 Oct;25(5):489-493. doi: 10.1177/1039856217706824. Epub 2017 Jul 13.

  PMID: 28703691 BACKGROUND

• Bakhaidar M, Jan S, Farahat F, Attar A, Alsaywid B, Abuznadah W. Pattern of drug overdose and chemical poisoning among patients attending an emergency department, western Saudi Arabia. J Community Health. 2015 Feb;40(1):57-61. doi: 10.1007/s10900-014-9895-x.

  PMID: 24927975 BACKGROUND

• Jayakrishnan B, Al Asmi A, Al Qassabi A, Nandhagopal R, Mohammed I. Acute drug overdose: clinical profile, etiologic spectrum and determinants of duration of intensive medical treatment. Oman Med J. 2012 Nov;27(6):501-4. doi: 10.5001/omj.2012.120.

  PMID: 23226824 BACKGROUND

• Savage M, Kung R, Green C, Thia B, Perera D, Tiruvoipati R. Predictors of ICU admission and long-term outcomes in overdose presentations to Emergency Department. Australas Psychiatry. 2020 Feb;28(1):75-79. doi: 10.1177/1039856219889317. Epub 2020 Jan 8.

  PMID: 31912753 BACKGROUND

• Tawfik, H., & Khalifa, E. (2017). Evaluation of Poisoning and Drug Overdose among Cases Presented to Poison Control Centre, Ain Shams University Hospital during the Year 2015. Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 29(2), 100-112.

  BACKGROUND

• Zhao M, Ji XP, Wang NN, Liu SY, Wang YZ. Study of poisoning pattern at China Medical University from 1997 to 2007. Public Health. 2009 Jun;123(6):454-5. doi: 10.1016/j.puhe.2009.04.010. Epub 2009 Jun 3. No abstract available.

  PMID: 19497600 BACKGROUND

• Cioccari L, Luethi N, Bailey M, Pilcher D, Bellomo R. Characteristics and outcomes of critically ill patients with drug overdose in Australia and New Zealand. Crit Care Resusc. 2017 Mar;19(1):14-22.

  PMID: 28215127 BACKGROUND

• Orsini, Jose, et al.

  BACKGROUND

MeSH Terms

Conditions

Drug-Related Side Effects and Adverse Reactions

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders

Central Study Contacts

Peter Eissa Saad

CONTACT

01276086545; Petereissa3@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Demonstrator at Forensic and clinical toxicology department

Study Record Dates

• First Submitted: July 7, 2021
• First Posted: August 3, 2021
• Study Start: April 1, 2021
• Primary Completion: March 31, 2022
• Study Completion: March 31, 2022
• Last Updated: August 3, 2021

Record last verified: 2021-07

Locations

EG (1)